Journal of Pharmaceutical Sciences 1976-10-01

Selectivity of 4-methoxyphenethylamine derivatives as inhibitors of monoamine oxidase.

W J Keller, G G Ferguson

Index: J. Pharm. Sci. 65(10) , 1539-40, (1976)

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Abstract

It has been established that the oxidative deamination of tyramine by monoamine xodase is inhibited by (+/-)-4-methoxy-beta-hydroxyphenethylamine and its N-methylated derivatives. This particular series of compounds does not inhibit the action of monoamine oxidase when tryptamine is used as the substrate. In contrast, 4-methoxyphenethylamine and its N-methylated homologs inhibit the monoamine oxidase-catalyzed deamination of both tyramine and tryptamine.