Radiobiologiia 1993-01-01

[An increase in the radioprotective effect of O-methyltyramine and mezaton by monoamine oxidase inhibitors].

V I Kulinskiĭ, V Z Gorkin, A D Klimova, N P Rumiantseva

Index: Radiobiologiia 33(1) , 137-40, (1993)

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Abstract

Specific 2-propynylamine inhibitors of monoamine oxidase (MAO) pargyline and especially chlorgyline, a selective inhibitor of MAO A (but not deprenyl, a selective inhibitor of MAO B) increase the radioprotective effect of small doses of O-methyltyramine and phenylephrine and do not change the efficacy of large doses. This is consistent with the receptor theory of the mechanism of protective action of amines.