Bioorganic & Medicinal Chemistry 2006-03-01

Synthesis of chalcone analogues with increased antileishmanial activity.

Paula Boeck, Camila Alves Bandeira Falcão, Paulo César Leal, Rosendo Augusto Yunes, Valdir Cechinel Filho, Eduardo Caio Torres-Santos, Bartira Rossi-Bergmann

Index: Bioorg. Med. Chem. 14(5) , 1538-45, (2006)

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Abstract

Eighteen analogues of an active natural chalcone were synthesized using xanthoxyline and some derivatives, and these analogues were tested for selective activity against both promastigotes and intracellular amastigotes of Leishmania amazonensis in vitro. Three analogues (10, 12, and 19) containing nitro, fluorine or bromine groups, respectively, displayed increased selective activity against the parasites as compared with the natural chalcone. The nitrosylated chalcone 10 was also tested intralesionally in infected mice and was found to be as effective as Pentostan reference drug at a dose 100 times higher than that of the chalcone in controlling both the lesion growth and the parasite burden.