Xanthoxylin
Xanthoxylin structure
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Common Name | Xanthoxylin | ||
|---|---|---|---|---|
| CAS Number | 90-24-4 | Molecular Weight | 196.200 | |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 355.1±37.0 °C at 760 mmHg | |
| Molecular Formula | C10H12O4 | Melting Point | 80-84 °C(lit.) | |
| MSDS | Chinese USA | Flash Point | 141.2±20.0 °C | |
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Collateral sensitivity of resistant MRP1-overexpressing cells to flavonoids and derivatives through GSH efflux.
Biochem. Pharmacol. 90(3) , 235-45, (2014) The multidrug resistance protein 1 (MRP1) is involved in multidrug resistance of cancer cells by mediating drug efflux out of cells, often in co-transport with glutathione (GSH). GSH efflux mediated by MRP1 can be stimulated by verapamil. In cells overexpress... |
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Antinociceptive action of 2-(4-bromobenzoyl)-3-methyl-4,6-dimethoxy benzofuran, a novel xanthoxyline derivative on chemical and thermal models of nociception in mice.
J. Pharmacol. Exp. Ther. 278(1) , 304-12, (1996) The antinociceptive effect of the novel xanthoxyline derivative 2-(4-bromobenzoyl)-3-methyl-4-6-dimethoxy benzofuran) (BMDB), given i.p., p.o., s.c., subplantarly, intrathecally or by i.c.v. routes was assessed in five models of chemical and thermal nocicepti... |
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Synthesis of chalcone analogues with increased antileishmanial activity.
Bioorg. Med. Chem. 14(5) , 1538-45, (2006) Eighteen analogues of an active natural chalcone were synthesized using xanthoxyline and some derivatives, and these analogues were tested for selective activity against both promastigotes and intracellular amastigotes of Leishmania amazonensis in vitro. Thre... |
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Antifungal activity and studies on mode of action of novel xanthoxyline-derived chalcones.
Arch. Pharm. (Weinheim) 338(2-3) , 87-95, (2005) Chalcones and chalcone-like compounds, most of them new ones, prepared by base-catalyzed condensation of appropriate aldehydes and xanthoxyline, were tested for antifungal properties against a panel of yeasts, hialohyphomycetes as well as dermatophytes with t... |
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Action of 2-hydroxy-4,6-dimethoxyacetophenone isolated from Sebastiania schottiana.
Planta Med. 56(1) , 31-5, (1990) The inhibitory action of the major constituent of Sebastiania schottiana (Euphorbiaceae), 2-hydroxy-4,6-dimethoxyacetophenone (xanthoxyline) on contractions induced by agonists and electrical stimulation of smooth and cardiac muscle preparations was analysed.... |
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Fungicide and fungiostatic effects of xanthoxyline.
J. Ethnopharmacol. 53(3) , 171-3, (1996)
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Antispasmodic activity of xanthoxyline derivatives: structure-activity relationships.
J. Pharm. Sci. 84(4) , 473-5, (1995) The antispasmodic activity of several xanthoxyline derivatives against acetylcholine-induced contraction of the guinea pig ileum was evaluated in vitro. The acetophenones with two methoxyl groups, mainly in the 3,4 positions, exhibited potent antispasmodic ac... |
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Antifeedant constituents from Fagara macrophylla.
Fitoterapia 72(5) , 538-43, (2001) Analysis of the polar fractions of an EtOH extract obtained from the bark of the African medicinal plant Fagara macrophylla led to the isolation and identification of the alkaloids oblongine (6), tembetarine (7) and magnoflorine (8) and the flavonoid hesperid... |
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Molecular structure and QSAR study on antispasmodic activity of some xanthoxyline derivatives.
Arch. Pharm. (Weinheim) 339(5) , 227-37, (2006) Semi-empirical molecular orbital calculations at AM1 level were done with the aim to investigate the structure-activity relationships of antispasmodic activities of ten 2-(X-benzyloxy)-4,6-dimethoxyacetophenones with X = H, 4'-F, 4'-NO2, 4'-CH3, 4'-Cl, 3',4'-... |
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Antinociceptive effects of synthetic chalcones obtained from xanthoxyline.
Arch. Pharm. (Weinheim) 339(7) , 361-5, (2006) A wide variety of noxious stimuli are known to induce a sensation of pain evoked in a remote region of the body. Here, we show that chalcones can inhibit the pain provoked by the administration of an intraperitoneal acetic acid (AA). This study investigates t... |