Journal of medicinal chemistry

Structure-anti-Parkinson activity relationships in the aminoadamantanes. Influence of bridgehead substitution

JG Henkel, JT Hane, G Gianutsos

Index: Henkel, James G.; Hane, Jeffrey T.; Gianutsos, Gerald Journal of Medicinal Chemistry, 1982 , vol. 25, # 1 p. 51 - 56

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Citation Number: 48

Abstract

A limited series of bridgehead alkyl-, dialkyl-, and trialkyl-substituted amantadine5 was synthesized and tested for potential anti-Parkinson activity as dopamine (DA) agonists. The compounds were evaluated using a battery of three murine bioassays, including stimulation of locomotor activity, induction of circling in animals with unilateral striatal lesions, and reversal of reserpine/a-methyltyrosine induced akinesia. Apparent mechanistic differences ...