Journal of the American Academy of Dermatology 1989-11-01

Topical corticosteroid compounding: effects on physicochemical stability and skin penetration rate.

L Krochmal, J C Wang, B Patel, J Rodgers

Index: J. Am. Acad. Dermatol. 21(5 Pt 1) , 979-84, (1989)

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Abstract

Compounding compatibility studies of four corticosteroid cream products and four commonly added chemicals are presented. Physical alteration, chemical stability, micropreservative challenge status, and in vitro skin penetration were evaluated at ambient conditions for 2 months. The study was designed to generate useful, previously unavailable information to aid dispensing pharmacists and dermatologists.