Desoximetasone
Modify Date: 2024-01-03 19:34:16
Desoximetasone structure
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Common Name | Desoximetasone | ||
|---|---|---|---|---|
| CAS Number | 382-67-2 | Molecular Weight | 376.462 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 532.3±50.0 °C at 760 mmHg | |
| Molecular Formula | C22H29FO4 | Melting Point | 217ºC | |
| MSDS | Chinese USA | Flash Point | 275.7±30.1 °C | |
| Symbol |
GHS07, GHS08 |
Signal Word | Warning | |
Use of DesoximetasoneDesoximetasone(Topicort) is a medication belonging to the family of medications known as topical corticosteroids; is used for the relief of various skin conditions, including rashes.IC50 value:Target: When using desoximetasone, some of the medication may be absorbed through the skin and into the bloodstream. Too much absorption can lead to unwanted side effects elsewhere in the body. To keep this problem to a minimum, avoid using large amounts of desoximetasone over large areas, do not use it for extended periods of time, and do not cover it with airtight dressings such as plastic wrap or adhesive bandages unless specifically told to by your doctor.[1] Children may absorb more medication than adults do. Desoximetasone is for use only on the skin and should be kept out of the eyes. |
| Name | desoximetasone |
|---|---|
| Synonym | More Synonyms |
| Description | Desoximetasone(Topicort) is a medication belonging to the family of medications known as topical corticosteroids; is used for the relief of various skin conditions, including rashes.IC50 value:Target: When using desoximetasone, some of the medication may be absorbed through the skin and into the bloodstream. Too much absorption can lead to unwanted side effects elsewhere in the body. To keep this problem to a minimum, avoid using large amounts of desoximetasone over large areas, do not use it for extended periods of time, and do not cover it with airtight dressings such as plastic wrap or adhesive bandages unless specifically told to by your doctor.[1] Children may absorb more medication than adults do. Desoximetasone is for use only on the skin and should be kept out of the eyes. |
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| Related Catalog | |
| References |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 532.3±50.0 °C at 760 mmHg |
| Melting Point | 217ºC |
| Molecular Formula | C22H29FO4 |
| Molecular Weight | 376.462 |
| Flash Point | 275.7±30.1 °C |
| Exact Mass | 376.204987 |
| PSA | 74.60000 |
| LogP | 2.20 |
| Vapour Pressure | 0.0±3.2 mmHg at 25°C |
| Index of Refraction | 1.574 |
| Storage condition | Refrigerator |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
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| Symbol |
GHS07, GHS08 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H302-H312-H315-H317-H319-H332-H335-H351 |
| Precautionary Statements | P261-P280-P305 + P351 + P338 |
| Personal Protective Equipment | Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges |
| Hazard Codes | Xn:Harmful; |
| Risk Phrases | R20/21/22;R36/37/38;R40;R43 |
| Safety Phrases | S22-S26-S36 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| RTECS | TU3834000 |
| HS Code | 2914700090 |
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~83%
Desoximetasone CAS#:382-67-2 |
| Literature: TARO PHARMACEUTICAL INDUSTRIES LTD.; CHERNIAK, Simon; CYJON, Rosa; OZER, Ilana; NUDELMAN, Igor Patent: WO2012/11106 A1, 2012 ; Location in patent: Page/Page column 15-16 ; |
| Precursor 1 | |
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| DownStream 1 | |
![(8S,9R,10S,11S,13S,14S,16R,17R)-9-fluoro-11-hydroxy-10,13,16-trimethyl-3-oxo-7,8,11,12,14,15,16,17-octahydro-6H-cyclopenta[a]phenanthrene-17-carboxylic acid structure](https://image.chemsrc.com/caspic/067/75262-69-0.png)
CAS#:75262-69-0| HS Code | 2914700090 |
|---|---|
| Summary | HS: 2914700090 halogenated, sulphonated, nitrated or nitrosated derivatives of ketones and quinones, whether or not with other oxygen function Tax rebate rate:9.0% Supervision conditions:none VAT:17.0% MFN tariff:5.5% General tariff:30.0% |
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The effects of dissociated glucocorticoids RU24858 and RU24782 on TPA-induced skin tumor promotion biomarkers in SENCAR mice.
Mol. Carcinog. 53(6) , 488-97, (2014) Glucocorticoids (GCs) are very effective at preventing carcinogen- and tumor promoter-induced skin inflammation, hyperplasia, and mouse skin tumor formation. The effects of GCs are mediated by a well-... |
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Photosensitivity to desoximetasone emollient cream.
Arch. Dermatol. 124(12) , 1870-1, (1988)
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Rapid assay of the anti-inflammatory activity of topical corticosteroids by inhibition of a UVA-induced neutrophil infiltration in hairless mouse skin. II. Assessment of name brand versus generic potency.
Acta Derm. Venereol. 74(1) , 18-9, (1994) The hairless mouse model of a UVA-induced dermal neutrophilic infiltrate was used to compare the efficacy of equal concentrations of name brand versus generic corticosteroids. The generic brand was si... |
| desoximetasonum [INN_la] |
| Desoximetasone |
| EINECS 206-845-3 |
| 9-Fluoro-11-β,21-dihydroxy-16-α-methylpregna-1,4-diene-3,20-dione |
| MFCD00083301 |
| desoximetasona [INN_es] |
| (11β,16α)-9-Fluoro-11,21-dihydroxy-16-methylpregna-1,4-diene-3,20-dione |
| Pregna-1,4-diene-3,20-dione, 9-fluoro-11,21-dihydroxy-16-methyl-, (11β,16α)- |
| desoximetasone [INN_en] |
| Desoxymetasone |