Nature Chemistry

A biomolecule-compatible visible-light-induced azide reduction from a DNA-encoded reaction-discovery system

Y Chen, AS Kamlet, JB Steinman, DR Liu

Index: Chen, Yiyun; Kamlet, Adam S.; Steinman, Jonathan B.; Liu, David R. Nature Chemistry, 2011 , vol. 3, # 2 p. 146 - 153

Full Text: HTML

Citation Number: 116

Abstract

Using a system that accelerates the serendipitous discovery of new reactions by evaluating hundreds of DNA-encoded substrate combinations in a single experiment, we explored a broad range of reaction conditions for new bond-forming reactions. We discovered reactivity that led to a biomolecule-compatible, Ru (II)-catalysed azide-reduction reaction induced by visible light. In contrast to current azide-reduction methods, this reaction is highly ...