Tetrahedron letters

Microwave-assisted synthesis of α-hydroxy ketone and α-diketone and pyrazine derivatives from α-halo and α, α′-dibromo ketone

T Utsukihara, H Nakamura, M Watanabe, CA Horiuchi

Index: Utsukihara, Takamitsu; Nakamura, Hiroaki; Watanabe, Masashige; Akira Horiuchi Tetrahedron Letters, 2006 , vol. 47, # 52 p. 9359 - 9364

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Citation Number: 24

Abstract

A novel reaction of α-halo ketone (α-bromo and α-chloro ketone) with irradiation under microwave gave the corresponding α-hydroxyketone and pyrazine derivative in good yields. In the case of α, α′-dibromo ketone, α-diketone was obtained. This reaction affords a new, clean and convenient synthetic method for α-hydroxyketone, α-diketone, α-chloro ketone and pyrazine derivative.

99-73-0

2,4′-dibromoace...

~82%

~82%

~73%

~63%

~83%

~66%

~67%

~79%

~76%

~78%

~94%

~71%

~89%

~71%

~84%

~84%

~90%

~86%

~92%

~18%

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