Nucleosides & nucleotides 1989-01-01

N-cyanoimidazole and diimidazole imine: water-soluble condensing agents for the formation of the phosphodiester bond.

J P Ferris, C H Huang, W J Hagan

Index: Nucleosides Nucleotides 8(3) , 407-14, (1989)

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Abstract

The reaction of BrCN with imidazole results in the formation of N-cyanoimidazole and diimidazole imine. These compounds were shown to be useful condensing agents for the formation of the phosphodiester bound in aqueous solution.