Adenosine, cyclic2',3'-(hydrogen phosphate), monosodium salt (9CI)
Adenosine, cyclic2',3'-(hydrogen phosphate), monosodium salt (9CI) structure
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Common Name | Adenosine, cyclic2',3'-(hydrogen phosphate), monosodium salt (9CI) | ||
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| CAS Number | 37063-35-7 | Molecular Weight | 369.203 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C10H11N5NaO6P | Melting Point | 241-243ºC (dec.)(lit.) | |
| MSDS | USA | Flash Point | N/A | |
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2',3'-cAMP, 3'-AMP, and 2'-AMP inhibit human aortic and coronary vascular smooth muscle cell proliferation via A2B receptors.
Am. J. Physiol. Heart Circ. Physiol. 301(2) , H391-401, (2011) Rat vascular smooth muscle cells (VSMCs) from renal microvessels metabolize 2',3'-cAMP to 2'-AMP and 3'-AMP, and these AMPs are converted to adenosine that inhibits microvascular VSMC proliferation via A(2B) receptors. The goal of this study was to test wheth... |
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The brain in vivo expresses the 2',3'-cAMP-adenosine pathway.
J. Neurochem. 122(1) , 115-25, (2012) Although multiple biochemical pathways produce adenosine, studies suggest that the 2',3'-cAMP-adenosine pathway (2',3'-cAMP→2'-AMP/3'-AMP→adenosine) contributes to adenosine production in some cells/tissues/organs. To determine whether the 2',3'-cAMP-adenosin... |
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Extracellular 2',3'-cAMP-adenosine pathway in proximal tubular, thick ascending limb, and collecting duct epithelial cells.
Am. J. Physiol. Renal Physiol. 304(1) , F49-55, (2013) In a previous study, we demonstrated that human proximal tubular epithelial cells obtained from a commercial source metabolized extracellular 2',3'-cAMP to 2'-AMP and 3'-AMP and extracellular 2'-AMP and 3'-AMP to adenosine (the extracellular 2',3'-cAMP-adenos... |
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2'-AMP and 3'-AMP inhibit proliferation of preglomerular vascular smooth muscle cells and glomerular mesangial cells via A2B receptors.
J. Pharmacol. Exp. Ther. 337 , 444-450, (2011) Studies show that kidneys produce 2',3'-cAMP, 2',3'-cAMP is exported and metabolized to 2'-AMP and 3'-AMP, 2'-AMP and 3'-AMP are metabolized to adenosine, 2',3'-cAMP inhibits proliferation of preglomerular vascular smooth muscle cells (PGVSMCs) and glomerular... |
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2',3'-cAMP hydrolysis by metal-dependent phosphodiesterases containing DHH, EAL, and HD domains is non-specific: Implications for PDE screening.
Biochem. Biophys. Res. Commun. 398 , 500-505, (2010) The recent report of 2',3'-cAMP isolated from rat kidney is the first proof of its biological existence, which revived interest in this mysterious molecule. 2',3'-cAMP serves as an extracellular adenosine source, but how it is degraded remains unclear. Here, ... |
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Extracellular 2,3-cyclic adenosine monophosphate is a potent inhibitor of preglomerular vascular smooth muscle cell and mesangial cell growth [corrected].
Hypertension 56 , 151-158, (2010) Recently we discovered that intact kidneys release into the extracellular compartment 2',3'-cAMP (a positional isomer of 3',5'-cAMP with unknown pharmacology) and metabolize 2',3'-cAMP to 2'-AMP, 3'-AMP, and adenosine. Because adenosine inhibits growth of vas... |
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N-cyanoimidazole and diimidazole imine: water-soluble condensing agents for the formation of the phosphodiester bond.
Nucleosides Nucleotides 8(3) , 407-14, (1989) The reaction of BrCN with imidazole results in the formation of N-cyanoimidazole and diimidazole imine. These compounds were shown to be useful condensing agents for the formation of the phosphodiester bound in aqueous solution. |
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The 2',3'-cAMP-adenosine pathway.
Am. J. Physiol. Renal Physiol. 301(6) , F1160-7, (2011) Our recent studies employing HPLC-tandem mass spectrometry to analyze venous perfusate from isolated, perfused kidneys demonstrate that intact kidneys produce and release into the extracellular compartment 2',3'-cAMP, a positional isomer of the second messeng... |
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The possible cyclic AMP-dependence of an early prereplicative event that determines mitosis in regenerating rat liver.
J. Cell Physiol. 124(3) , 397-402, (1985) The beta-adrenergic blocker dl-propranolol prevented a large proportion of regenerating rat liver cells from entering the mitotic phase of their first cell division cycle without affecting their ability to initiate or complete DNA replication. The drug, at a ... |
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Ca2+-dependent permeability transition regulation in rat brain mitochondria by 2',3'-cyclic nucleotides and 2',3'-cyclic nucleotide 3'-phosphodiesterase.
Am. J. Physiol. Cell Physiol. 296(6) , C1428-39, (2009) Recent evidence indicates that 2',3'-cyclic nucleotide 3'-phosphodiesterase (CNP), a marker enzyme of myelin and oligodendrocytes, is also present in neural and nonneural mitochondria. However, its role in mitochondria is still completely unclear. We found CN... |