Bioorganic & Medicinal Chemistry 2005-05-16

Syntheses of novel heterocycles as anticancer agents.

Prem M S Chauhan, Cristina J A Martins, David C Horwell

Index: Bioorg. Med. Chem. 13(10) , 3513-8, (2005)

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Abstract

Several pteridine analogues 4-13, 23-26 have been synthesized and tested in vitro against three cancer cell lines, MCF7 (breast), NCI-H460 (lung) and SF-268 (CNS). All tested pteridines can serve as novel templates for the anticancer chemotherapy and can serve as new leads in cancer chemotherapy.