6-(Chloromethyl)-2,4(1H,3H)-pyrimidinedione
6-(Chloromethyl)-2,4(1H,3H)-pyrimidinedione structure
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Common Name | 6-(Chloromethyl)-2,4(1H,3H)-pyrimidinedione | ||
|---|---|---|---|---|
| CAS Number | 18592-13-7 | Molecular Weight | 160.558 | |
| Density | 1.4±0.1 g/cm3 | Boiling Point | 493.9ºC at 760 mmHg | |
| Molecular Formula | C5H5ClN2O2 | Melting Point | 257 °C (dec.)(lit.) | |
| MSDS | Chinese USA | Flash Point | 252.5ºC | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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Synthesis and enzymatic evaluation of pyridinium-substituted uracil derivatives as novel inhibitors of thymidine phosphorylase.
Bioorg. Med. Chem. 10(3) , 525-30, (2002) A series of water soluble N(1)- and C(6)-substituted uracil pyridinium compounds were prepared as potential inhibitors of thymidine phosphorylase (TP). The C(6)-uracil substituted derivatives were the most active. 1-[(5-Chloro-2,4-dihydroxypyrimidin-6-yl)meth... |
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Synthesis and evaluation of 6-methylene-bridged uracil derivatives. Part 1: discovery of novel orally active inhibitors of human thymidine phosphorylase.
Bioorg. Med. Chem. 12(13) , 3431-41, (2004) A series of novel 6-methylene-bridged uracil derivatives have been prepared as inhibitors of human thymidine phosphorylase (TP). To enhance the in vivo antitumor activity of fluorinated pyrimidine 2'-deoxyribonucleosides such as 2'-deoxy-5-(trifluoromethyl)ur... |
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Syntheses of novel heterocycles as anticancer agents.
Bioorg. Med. Chem. 13(10) , 3513-8, (2005) Several pteridine analogues 4-13, 23-26 have been synthesized and tested in vitro against three cancer cell lines, MCF7 (breast), NCI-H460 (lung) and SF-268 (CNS). All tested pteridines can serve as novel templates for the anticancer chemotherapy and can serv... |
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Secondary radical attack on DNA nucleotides: reaction by addition to DNA bases and abstraction from sugars.
Int. J. Radiat. Biol. 71(4) , 387-99, (1997) In this work radicals generated by dissociative electron attachment to iodoacetamide (H2NCOCH2.) and 6-chloromethyluracil (U5CH2.) are suggested to react with DNA nucleotides in frozen aqueous solutions via either hydrogen abstraction or addition to the doubl... |
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[Synthesis of New Uracil Derivatives / On the reactability of 4-chloromethyluracil (author's transl)].
Arzneimittelforschung 30(2) , 228-31, (1980) The synthesis of new uracil derivatives is described. In 4-chloromethyluracil, chlorine can be easily exchanged under mild conditions for amine, aniline, hydrazine, and phenol. |