Chemical Communications 2003-08-07

A long-range chiral relay via tertiary amide group in asymmetric catalysis: new amino acid-derived N,P-ligands for copper-catalysed conjugate addition.

Andrei V Malkov, John B Hand, Pavel Kocovský

Index: Chem. Commun. (Camb.) (15) , 1948-9, (2003)

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Abstract

New N,P-ligands 4-6, derived from valinol and prolinol, respectively, have been developed for the asymmetric, copper(I)-catalysed conjugate addition of diethylzinc to unsaturated ketones; the tertiary amide group has been shown to effectively relay the chiral information from the ligand backbone to the active centre.