e.g. Filippa Pettersson or Cancer Res. 75(6) , 1102-12, (2015) or 10.1002/anie.201600521

Potential of lichen secondary metabolites against Plasmodium liver stage parasites with FAS-II as the potential target

IL Lauinger, L Vivas, R Perozzo…

Index: Pattenden, Gerald; Pegg, Neil A.; Kenyon, Ronald W. Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1991 , # 10 p. 2363 - 2372

Full Text: HTML

Citation Number: 16

Abstract

... Journal of Natural ... 1070. DOI: 10.1021/np400083k. Publication Date (Web): June 19, 2013. Copyright © 2013 The American Chemical Society and American ... and development of LS parasites was assessed by immunofluorescence analysis (Figure 1). In accordance with the qRT ...

6-Benzyliden-3-hydroxy-4-phenyl-2H-pyran-2,5(6H)-dion Structure

6-Benzyliden-3-...

~90%

2,5-Dihydroxy-3,6-diphenyl-p-benzoquinone Structure

2,5-Dihydroxy-3...

3-hydroxy-1,4-diphenylbutan-2-one Structure

3-hydroxy-1,4-d...

~%

2,5-Dihydroxy-3,6-diphenyl-p-benzoquinone Structure

2,5-Dihydroxy-3...

α-((trimethylsilyl)oxy)benzenepropanenitrile Structure

α-((trimethylsi...

~%

2,5-Dihydroxy-3,6-diphenyl-p-benzoquinone Structure

2,5-Dihydroxy-3...

3-hydroxy-4-phenyl-6-(phenylmethyl)-2H-pyran-2,5(6H)-dione Structure

3-hydroxy-4-phe...

~%

2,5-Dihydroxy-3,6-diphenyl-p-benzoquinone Structure

2,5-Dihydroxy-3...

3-methoxy-4-phenyl-6-(phenylmethyl)-2H-pyran-2,5(6H)-dione Structure

3-methoxy-4-phe...

~%

2,5-Dihydroxy-3,6-diphenyl-p-benzoquinone Structure

2,5-Dihydroxy-3...

N/A Structure

~%

2,5-Dihydroxy-3,6-diphenyl-p-benzoquinone Structure

2,5-Dihydroxy-3...

3-oxo-1,4-diphenylbutan-2-yl ethyl oxalate Structure

3-oxo-1,4-diphe...

~%

2,5-Dihydroxy-3,6-diphenyl-p-benzoquinone Structure

2,5-Dihydroxy-3...

Phenylacetaldehyde Structure

Phenylacetaldehyde

~%

2,5-Dihydroxy-3,6-diphenyl-p-benzoquinone Structure

2,5-Dihydroxy-3...

Benzyl magnesium bromide Structure

Benzyl magnesiu...

α-((trimethylsilyl)oxy)benzenepropanenitrile Structure

α-((trimethylsi...

~%

3-hydroxy-1,4-diphenylbutan-2-one Structure

3-hydroxy-1,4-d...

4-methoxy-α[(trimethylsilyl)oxy]benzenepropanenitrile Structure

4-methoxy-α[(tr...

~%

2,5-dihydroxy-3-(4-methoxyphenyl)-6-phenylcyclohexa-2,5-diene-1,4-dione Structure

2,5-dihydroxy-3...

3-hydroxy-4-(4'-methoxyphenyl)-1-phenylbutan-2-one Structure

3-hydroxy-4-(4'...

~%

2,5-dihydroxy-3-(4-methoxyphenyl)-6-phenylcyclohexa-2,5-diene-1,4-dione Structure

2,5-dihydroxy-3...

3-hydroxy-6-(4-methoxybenzyl)-4-phenylpyran-2,5-dione Structure

3-hydroxy-6-(4-...

~%

2,5-dihydroxy-3-(4-methoxyphenyl)-6-phenylcyclohexa-2,5-diene-1,4-dione Structure

2,5-dihydroxy-3...

N/A Structure

~%

2,5-dihydroxy-3-(4-methoxyphenyl)-6-phenylcyclohexa-2,5-diene-1,4-dione Structure

2,5-dihydroxy-3...

ethyl 1-(4-methoxyphenyl)-4-phenyl-3-oxobutan-2-yl oxalate Structure

ethyl 1-(4-meth...

~%

2,5-dihydroxy-3-(4-methoxyphenyl)-6-phenylcyclohexa-2,5-diene-1,4-dione Structure

2,5-dihydroxy-3...

6-bromo-3-methoxy-6-(4-methoxybenzyl)-4-phenylpyran-2,5-dione Structure

6-bromo-3-metho...

~%

2,5-dihydroxy-3-(4-methoxyphenyl)-6-phenylcyclohexa-2,5-diene-1,4-dione Structure

2,5-dihydroxy-3...

2-(4-Methoxyphenyl)acetaldehyde Structure

2-(4-Methoxyphe...

~%

2,5-dihydroxy-3-(4-methoxyphenyl)-6-phenylcyclohexa-2,5-diene-1,4-dione Structure

2,5-dihydroxy-3...

2,5-Dihydroxy-3,6-diphenyl-p-benzoquinone Structure

2,5-Dihydroxy-3...

~90%

Pulvinic anhydride Structure

Pulvinic anhydride

3-hydroxy-1,4-diphenylbutan-2-one Structure

3-hydroxy-1,4-d...

~%

Pulvinic anhydride Structure

Pulvinic anhydride

α-((trimethylsilyl)oxy)benzenepropanenitrile Structure

α-((trimethylsi...

~%

Pulvinic anhydride Structure

Pulvinic anhydride

3-hydroxy-4-phenyl-6-(phenylmethyl)-2H-pyran-2,5(6H)-dione Structure

3-hydroxy-4-phe...

~%

Pulvinic anhydride Structure

Pulvinic anhydride

3-methoxy-4-phenyl-6-(phenylmethyl)-2H-pyran-2,5(6H)-dione Structure

3-methoxy-4-phe...

~%

Pulvinic anhydride Structure

Pulvinic anhydride

N/A Structure

~%

Pulvinic anhydride Structure

Pulvinic anhydride

3-oxo-1,4-diphenylbutan-2-yl ethyl oxalate Structure

3-oxo-1,4-diphe...

~%

Pulvinic anhydride Structure

Pulvinic anhydride

6-Benzyliden-3-hydroxy-4-phenyl-2H-pyran-2,5(6H)-dion Structure

6-Benzyliden-3-...

~%

Pulvinic anhydride Structure

Pulvinic anhydride

Phenylacetaldehyde Structure

Phenylacetaldehyde

~%

Pulvinic anhydride Structure

Pulvinic anhydride

Methanol Structure

Pulvinic anhydride Structure

Pulvinic anhydride

~93%

Vulpic acid Structure

6-Benzyliden-3-hydroxy-4-phenyl-2H-pyran-2,5(6H)-dion Structure

6-Benzyliden-3-...

~%

Vulpic acid Structure

3-hydroxy-1,4-diphenylbutan-2-one Structure

3-hydroxy-1,4-d...

~%

Vulpic acid Structure

2,5-Dihydroxy-3,6-diphenyl-p-benzoquinone Structure

2,5-Dihydroxy-3...

~%

Vulpic acid Structure

Phenylacetaldehyde Structure

Phenylacetaldehyde

~%

Vulpic acid Structure

α-((trimethylsilyl)oxy)benzenepropanenitrile Structure

α-((trimethylsi...

~%

Vulpic acid Structure

3-hydroxy-4-phenyl-6-(phenylmethyl)-2H-pyran-2,5(6H)-dione Structure

3-hydroxy-4-phe...

~%

Vulpic acid Structure

3-methoxy-4-phenyl-6-(phenylmethyl)-2H-pyran-2,5(6H)-dione Structure

3-methoxy-4-phe...

~%

Vulpic acid Structure

N/A Structure

~%

Vulpic acid Structure

3-oxo-1,4-diphenylbutan-2-yl ethyl oxalate Structure

3-oxo-1,4-diphe...

~%

Vulpic acid Structure

3-hydroxy-1,4-diphenylbutan-2-one Structure

3-hydroxy-1,4-d...

~%

(αE)-α-[3-Hydroxy-4-phenyl-5-oxofuran-2(5H)-ylidene]benzeneacetic acid Structure

(αE)-α-[3-Hydro...

α-((trimethylsilyl)oxy)benzenepropanenitrile Structure

α-((trimethylsi...

~%

(αE)-α-[3-Hydroxy-4-phenyl-5-oxofuran-2(5H)-ylidene]benzeneacetic acid Structure

(αE)-α-[3-Hydro...

3-hydroxy-4-phenyl-6-(phenylmethyl)-2H-pyran-2,5(6H)-dione Structure

3-hydroxy-4-phe...

~%

(αE)-α-[3-Hydroxy-4-phenyl-5-oxofuran-2(5H)-ylidene]benzeneacetic acid Structure

(αE)-α-[3-Hydro...

3-methoxy-4-phenyl-6-(phenylmethyl)-2H-pyran-2,5(6H)-dione Structure

3-methoxy-4-phe...

~%

(αE)-α-[3-Hydroxy-4-phenyl-5-oxofuran-2(5H)-ylidene]benzeneacetic acid Structure

(αE)-α-[3-Hydro...

N/A Structure

~%

(αE)-α-[3-Hydroxy-4-phenyl-5-oxofuran-2(5H)-ylidene]benzeneacetic acid Structure

(αE)-α-[3-Hydro...

3-oxo-1,4-diphenylbutan-2-yl ethyl oxalate Structure

3-oxo-1,4-diphe...

~%

(αE)-α-[3-Hydroxy-4-phenyl-5-oxofuran-2(5H)-ylidene]benzeneacetic acid Structure

(αE)-α-[3-Hydro...

2,5-Dihydroxy-3,6-diphenyl-p-benzoquinone Structure

2,5-Dihydroxy-3...

~%

(αE)-α-[3-Hydroxy-4-phenyl-5-oxofuran-2(5H)-ylidene]benzeneacetic acid Structure

(αE)-α-[3-Hydro...

6-Benzyliden-3-hydroxy-4-phenyl-2H-pyran-2,5(6H)-dion Structure

6-Benzyliden-3-...

~%

(αE)-α-[3-Hydroxy-4-phenyl-5-oxofuran-2(5H)-ylidene]benzeneacetic acid Structure

(αE)-α-[3-Hydro...

Phenylacetaldehyde Structure

Phenylacetaldehyde

~%

(αE)-α-[3-Hydroxy-4-phenyl-5-oxofuran-2(5H)-ylidene]benzeneacetic acid Structure

(αE)-α-[3-Hydro...

(E)-[3-Methoxy-5-oxo-4-phenylfuran-2(5H)-ylidene]phenylacetic acid methyl ester Structure

(E)-[3-Methoxy-...

~%

(αE)-α-[3-Hydroxy-4-phenyl-5-oxofuran-2(5H)-ylidene]benzeneacetic acid Structure

(αE)-α-[3-Hydro...

Synthesis of a focused chemical library based on derivatives...

[Viault, Guillaume; Gree, Danielle; Das, Saibal; Yadav, Jhillu Singh; Gree, Rene European Journal of Organic Chemistry, 2011 , # 7 p. 1233 - 1241]

Alkylation of para quinones with acyl peroxides

[Fieser; Oxford Journal of the American Chemical Society, 1942 , vol. 64, p. 2063]

Preparation and the results of antitumor screening of some s...

[Zee-Cheng,K.-Y.; Cheng,C.C. Journal of Medicinal Chemistry, 1970 , vol. 13, p. 264 - 268]

Synthesis of a focused chemical library based on derivatives...

[Viault, Guillaume; Gree, Danielle; Das, Saibal; Yadav, Jhillu Singh; Gree, Rene European Journal of Organic Chemistry, 2011 , # 7 p. 1233 - 1241]

Synthesis of a focused chemical library based on derivatives...

[Viault, Guillaume; Gree, Danielle; Das, Saibal; Yadav, Jhillu Singh; Gree, Rene European Journal of Organic Chemistry, 2011 , # 7 p. 1233 - 1241]