Vulpic acid

Modify Date: 2025-08-25 11:24:09

Vulpic acid structure	Common Name	Vulpic acid
	CAS Number	521-52-8	Molecular Weight	322.31
	Density	1.375g/cm3	Boiling Point	568.8ºC at 760mmHg
	Molecular Formula	C₁₉H₁₄O₅	Melting Point	146-148ºC
	MSDS	N/A	Flash Point	210.2ºC

Use of Vulpic acid

Vulpinic acid, a lichen metabolite, decreases H2O2-induced ROS production, oxidative stress and oxidative stress-related damages in human umbilical vein endothelial cells (HUVEC). Vulpinic acid is active against staphylococci, enterococci, and anaerobic bacteria.Vulpinic acid has the potential for atherosclerosis research[1][2].

Name	Vulpinic Acid
Synonym	More Synonyms

Description	Vulpinic acid, a lichen metabolite, decreases H2O2-induced ROS production, oxidative stress and oxidative stress-related damages in human umbilical vein endothelial cells (HUVEC). Vulpinic acid is active against staphylococci, enterococci, and anaerobic bacteria.Vulpinic acid has the potential for atherosclerosis research[1][2].
Related Catalog	Research Areas >> Infection Research Areas >> Inflammation/Immunology Signaling Pathways >> Anti-infection >> Bacterial
References	[1]. E Sahin, et al. Vulpinic acid, a lichen metabolite, emerges as a potential drug candidate in the therapy of oxidative stress-related diseases, such as atherosclerosis. Hum Exp Toxicol. 2019 Jun;38(6):675-684. [2]. M Lauterwein, et al. In vitro activities of the lichen secondary metabolites vulpinic acid, (+)-usnic acid, and (-)-usnic acid against aerobic and anaerobic microorganisms. Antimicrob Agents Chemother. 1995 Nov;39(11):2541-3.

Description

Related Catalog

Research Areas >> Infection

Research Areas >> Inflammation/Immunology

Signaling Pathways >> Anti-infection >> Bacterial

References

[1]. E Sahin, et al. Vulpinic acid, a lichen metabolite, emerges as a potential drug candidate in the therapy of oxidative stress-related diseases, such as atherosclerosis. Hum Exp Toxicol. 2019 Jun;38(6):675-684.

[2]. M Lauterwein, et al. In vitro activities of the lichen secondary metabolites vulpinic acid, (+)-usnic acid, and (-)-usnic acid against aerobic and anaerobic microorganisms. Antimicrob Agents Chemother. 1995 Nov;39(11):2541-3.

Density	1.375g/cm3
Boiling Point	568.8ºC at 760mmHg
Melting Point	146-148ºC
Molecular Formula	C₁₉H₁₄O₅
Molecular Weight	322.31
Flash Point	210.2ºC
Exact Mass	322.08400
PSA	72.83000
LogP	3.09680
Index of Refraction	1.656
Storage condition	-20°C Freezer

CHEMICAL IDENTIFICATION

RTECS NUMBER :: HF3500000

CHEMICAL NAME :: Delta(sup 2(5H),alpha)-furanacetic acid, 3-hydroxy-5-oxo-alpha,4-diphenyl-, methyl ester

CAS REGISTRY NUMBER :: 521-52-8

LAST UPDATED :: 199612

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C19-H14-O5

MOLECULAR WEIGHT :: 322.33

WISWESSER LINE NOTATION :: T5VOYJ CUYR&VO1 DQ ER

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NCNSA6 National Academy of Sciences, National Research Council, Chemical-Biological Coordination Center, Review. (Washington, DC) Volume(issue)/page/year: 5,30,1953

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 75 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark) V.1-59, 1945-86. For publisher information, see PHTOEH Volume(issue)/page/year: 2,109,1946

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 180 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) Volume(issue)/page/year: NX#02804

Risk Phrases	28
Safety Phrases	1-22-45
RIDADR	UN 3172

Precursor 9
CAS#:79-37-8 Oxalyl chloride CAS#:40195-27-5 Diethoxy(phenyl... CAS#:67-56-1 Methanol CAS#:6273-79-6 Pulvinic anhydride
CAS#:15206-55-0 Methyl phenylgl... CAS#:57740-69-9 6-Benzyliden-3-... CAS#:6838-54-6 3-hydroxy-1,4-d... CAS#:548-59-4 2,5-Dihydroxy-3...
CAS#:122-78-1 Phenylacetaldehyde
DownStream 1
CAS#:26548-70-9 (αE)-α-[3-Hydro...