Tetrahedron Letters

Synthesis of bioactive 1-alkyl-1H-naphtho [2, 3-d][1, 2, 3] triazole-4, 9-diones and N-aryl-2-aminomethylene-1, 3-indanediones using water as the solvent

Q Zhang, JP Shrestha, CWT Chang

Index: Zhang, Qian; Shrestha, Jaya P.; Chang, Cheng-Wei Tom Tetrahedron Letters, 2014 , vol. 55, # 10 p. 1839 - 1842

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Citation Number: 6

Abstract

Abstract Through a [2+ 3] cycloaddition reaction, a new environmentally friendly method was developed to enable the synthesis of bioactive 1-alkyl-1H-naphtho [2, 3-d][1, 2, 3] triazole-4, 9-diones and N-aryl-2-aminomethylene-1, 3-indanediones using water as the solvent with good yields and minimum requirement of purification. This new green synthetic protocol is simple and suitable for scale-up synthesis.