1H-Naphtho(2,3-d)-1,2,3-triazole-4,9-dione, 1-phenyl-

Modify Date: 2025-08-26 11:50:39

1H-Naphtho(2,3-d)-1,2,3-triazole-4,9-dione, 1-phenyl- structure	Common Name	1H-Naphtho(2,3-d)-1,2,3-triazole-4,9-dione, 1-phenyl-
	CAS Number	5466-47-7	Molecular Weight	275.26
	Density	1.44g/cm3	Boiling Point	523.4ºC at 760 mmHg
	Molecular Formula	C₁₆H₉N₃O₂	Melting Point	N/A
	MSDS	N/A	Flash Point	270.3ºC

Use of 1H-Naphtho(2,3-d)-1,2,3-triazole-4,9-dione, 1-phenyl-

IDO1/TDO-IN-2 (Compound 1) is a potent inhibitor of IDO1/TDO with IC50s of 0.1 and 0.07 μM. IDO1/TDO-IN-2 has the potential for the research of cancer diseases[1].

Name	3-phenylbenzo[f]benzotriazole-4,9-dione

Description	IDO1/TDO-IN-2 (Compound 1) is a potent inhibitor of IDO1/TDO with IC50s of 0.1 and 0.07 μM. IDO1/TDO-IN-2 has the potential for the research of cancer diseases[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Metabolic Enzyme/Protease >> Indoleamine 2,3-Dioxygenase (IDO)
References	[1]. Pan S, et al. Discovery and structure-activity relationship studies of 1-aryl-1H-naphtho[2,3-d][1,2,3]triazole-4,9-dione derivatives as potent dual inhibitors of indoleamine 2,3-dioxygenase 1 (IDO1) and trytophan 2,3-dioxygenase (TDO). Eur J Med Chem. 2020 Dec 1;207:112703.

Density	1.44g/cm3
Boiling Point	523.4ºC at 760 mmHg
Molecular Formula	C₁₆H₉N₃O₂
Molecular Weight	275.26
Flash Point	270.3ºC
Exact Mass	275.06900
PSA	64.85000
LogP	2.04270
Index of Refraction	1.75
InChIKey	KXGSYSDSQRXROA-UHFFFAOYSA-N
SMILES	O=C1c2ccccc2C(=O)c2c1nnn2-c1ccccc1

HS Code	2933990090

Benzene, azido-

CAS#:622-37-7

1,4-naphthoquinone

CAS#:130-15-4

~26%

1H-Naphtho(2,3-...

CAS#:5466-47-7

Literature: Shrestha, Jaya P.; Fosso, Marina Y.; Bearss, Jeremiah; Chang, Cheng-Wei Tom European Journal of Medicinal Chemistry, 2014 , vol. 77, p. 96 - 102

Benzene, azido-

CAS#:622-37-7

1,4-naphthoquinone

CAS#:130-15-4

~23%

2-((phenylamino...

CAS#:38337-19-8

1H-Naphtho(2,3-...

CAS#:5466-47-7

Literature: Zhang, Qian; Shrestha, Jaya P.; Chang, Cheng-Wei Tom Tetrahedron Letters, 2014 , vol. 55, # 10 p. 1839 - 1842

CAS#:74497-02-2

1H-Naphtho(2,3-...

CAS#:5466-47-7

Literature: Zhang, Qian; Shrestha, Jaya P.; Chang, Cheng-Wei Tom Tetrahedron Letters, 2014 , vol. 55, # 10 p. 1839 - 1842

2-amino-3-anili...

CAS#:137660-75-4

1H-Naphtho(2,3-...

CAS#:5466-47-7

Literature: Fries; Billig Chemische Berichte, 1925 , vol. 58, p. 1133

2-amino-3-(N-ni...

CAS#:412312-83-5

1H-Naphtho(2,3-...

CAS#:5466-47-7

Literature: Fries; Billig Chemische Berichte, 1925 , vol. 58, p. 1133

N/A

CAS#:113689-75-1

1H-Naphtho(2,3-...

CAS#:5466-47-7

Literature: Fries; Billig Chemische Berichte, 1925 , vol. 58, p. 1133

Precursor 4
CAS#:622-37-7 Benzene, azido- CAS#:130-15-4 1,4-naphthoquinone CAS#:137660-75-4 2-amino-3-anili... CAS#:412312-83-5 2-amino-3-(N-ni...
DownStream 0

HS Code	2933990090
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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Product Name: 1H-Naphtho(2,3-d)-1,2,3-triazole-4,9-dione, 1-phenyl-
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Use of 1H-Naphtho(2,3-d)-1,2,3-triazole-4,9-dione, 1-phenyl-

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The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.