Synlett

TiCl4-mediated direct N-alkylation of sulfonamides with inactive ethers

J Chen, L Dang, Q Li, Y Ye, S Fu, W Zeng

Index: Chen, Jiayan; Dang, Ling; Li, Qiang; Ye, Yong; Fu, Shaomin; Zeng, Wei Synlett, 2012 , # 4 p. 595 - 600

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Citation Number: 6

Abstract

Abstract A TiCl 4-mediated intermolecular or intramolecular direct N-alkylation reaction of sulfonamides with inactive ethers as alkylating agents was successfully achieved. This method provides a novel approach towards N-alkyl sulfonamides from inactive ethers via an easy workup procedure.

~63%

~70%

~71%

~38%

~49%

~77%

~68%

~33%

~76%

~56%

~18%

~69%

~62%

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