UNC1215
UNC1215 structure
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Common Name | UNC1215 | ||
|---|---|---|---|---|
| CAS Number | 1415800-43-9 | Molecular Weight | 529.716 | |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 712.1±60.0 °C at 760 mmHg | |
| Molecular Formula | C32H43N5O2 | Melting Point | N/A | |
| MSDS | USA | Flash Point | 384.5±32.9 °C | |
Use of UNC1215UNC1215 is a potent and selective chemical probe for the methyllysine (Kme) reading function of L3MBTL3 with Kd value of 120 nM.IC50 Value: 120 nM (Kd) [1]Target: L3MBTL3 In vitro: UNC1215 binds L3MBTL3 with a K(d) of 120 nM, competitively displacing mono- or dimethyllysine-containing peptides, and is greater than 50-fold more potent toward L3MBTL3 than other members of the MBT family while also demonstrating selectivity against more than 200 other reader domains examined. X-ray crystallography identified a unique 2:2 polyvalent mode of interaction between UNC1215 and L3MBTL3. In cells, UNC1215 is nontoxic and directly binds L3MBTL3 via the Kme-binding pocket of the MBT domains. UNC1215 increases the cellular mobility of GFP-L3MBTL3 fusion proteins, and point mutants that disrupt the Kme-binding function of GFP-L3MBTL3 phenocopy the effects of UNC1215 on localization [1]. |
This table lists Chinese names, IUPAC names and various aliases of this chemical substance.
| Name | unc1215 |
|---|---|
| Synonym | More Synonyms |
This table contains bioactivity, target information and biological‑assay experimental data of this compound.
| Description | UNC1215 is a potent and selective chemical probe for the methyllysine (Kme) reading function of L3MBTL3 with Kd value of 120 nM.IC50 Value: 120 nM (Kd) [1]Target: L3MBTL3 In vitro: UNC1215 binds L3MBTL3 with a K(d) of 120 nM, competitively displacing mono- or dimethyllysine-containing peptides, and is greater than 50-fold more potent toward L3MBTL3 than other members of the MBT family while also demonstrating selectivity against more than 200 other reader domains examined. X-ray crystallography identified a unique 2:2 polyvalent mode of interaction between UNC1215 and L3MBTL3. In cells, UNC1215 is nontoxic and directly binds L3MBTL3 via the Kme-binding pocket of the MBT domains. UNC1215 increases the cellular mobility of GFP-L3MBTL3 fusion proteins, and point mutants that disrupt the Kme-binding function of GFP-L3MBTL3 phenocopy the effects of UNC1215 on localization [1]. |
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| Related Catalog | |
| References |
This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.
| Density | 1.2±0.1 g/cm3 |
|---|---|
| Boiling Point | 712.1±60.0 °C at 760 mmHg |
| Molecular Formula | C32H43N5O2 |
| Molecular Weight | 529.716 |
| Flash Point | 384.5±32.9 °C |
| Exact Mass | 529.341675 |
| PSA | 59.13000 |
| LogP | 3.37 |
| Appearance of Characters | white to beige |
| Vapour Pressure | 0.0±2.3 mmHg at 25°C |
| Index of Refraction | 1.640 |
| InChIKey | PQOOIERVZAXHBP-UHFFFAOYSA-N |
| SMILES | O=C(c1ccc(C(=O)N2CCC(N3CCCC3)CC2)c(Nc2ccccc2)c1)N1CCC(N2CCCC2)CC1 |
| Storage condition | 2-8°C |
| Water Solubility | DMSO: soluble5mg/mL, clear |
This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.
| RIDADR | NONH for all modes of transport |
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This table contains target information, in‑vitro & in‑vivo assay data for this compound.
This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.
| (2-Anilino-1,4-phenylene)bis{[4-(1-pyrrolidinyl)-1-piperidinyl]methanone} |
This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.
| Q: What is the LogP of unc1215? |
| A: LogP of unc1215 is 3.37. |
| Q: What is the polar surface area (PSA) of unc1215? |
| A: Polar surface area (PSA) of unc1215 is 59.13000. |
| Q: What is the molecular formula of unc1215? |
| A: Molecular formula of unc1215 is C32H43N5O2. |
| Q: What is the InChIKey of unc1215? |
| A: InChIKey of unc1215 is PQOOIERVZAXHBP-UHFFFAOYSA-N. |
| Q: What is the boiling point of unc1215? |
| A: Boiling point of unc1215 is 712.1±60.0 °C at 760 mmHg. |
| Q: What is the physical appearance of unc1215? |
| A: unc1215 appears as white to beige. |
| Q: What is the SMILES notation of unc1215? |
| A: SMILES notation of unc1215 is O=C(c1ccc(C(=O)N2CCC(N3CCCC3)CC2)c(Nc2ccccc2)c1)N1CCC(N2CCCC2)CC1. |
| Q: What are the storage conditions for unc1215? |
| A: Storage conditions for unc1215: 2-8°C. |
| Q: What is the molecular weight of unc1215? |
| A: Molecular weight of unc1215 is 529.716. |
| Q: What is the CAS number of unc1215? |
| A: CAS number of unc1215 is 1415800-43-9. |
This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.
| Shanghai Nianxing Industrial Co., Ltd |