Name | unc1215 |
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Synonyms |
(2-Anilino-1,4-phenylene)bis{[4-(1-pyrrolidinyl)-1-piperidinyl]methanone}
Methanone, 1,1'-[2-(phenylamino)-1,4-phenylene]bis[1-[4-(1-pyrrolidinyl)-1-piperidinyl]- |
Description | UNC1215 is a potent and selective chemical probe for the methyllysine (Kme) reading function of L3MBTL3 with Kd value of 120 nM.IC50 Value: 120 nM (Kd) [1]Target: L3MBTL3 In vitro: UNC1215 binds L3MBTL3 with a K(d) of 120 nM, competitively displacing mono- or dimethyllysine-containing peptides, and is greater than 50-fold more potent toward L3MBTL3 than other members of the MBT family while also demonstrating selectivity against more than 200 other reader domains examined. X-ray crystallography identified a unique 2:2 polyvalent mode of interaction between UNC1215 and L3MBTL3. In cells, UNC1215 is nontoxic and directly binds L3MBTL3 via the Kme-binding pocket of the MBT domains. UNC1215 increases the cellular mobility of GFP-L3MBTL3 fusion proteins, and point mutants that disrupt the Kme-binding function of GFP-L3MBTL3 phenocopy the effects of UNC1215 on localization [1]. |
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Related Catalog | |
References |
Density | 1.2±0.1 g/cm3 |
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Boiling Point | 712.1±60.0 °C at 760 mmHg |
Molecular Formula | C32H43N5O2 |
Molecular Weight | 529.716 |
Flash Point | 384.5±32.9 °C |
Exact Mass | 529.341675 |
PSA | 59.13000 |
LogP | 3.37 |
Appearance | white to beige |
Vapour Pressure | 0.0±2.3 mmHg at 25°C |
Index of Refraction | 1.640 |
Storage condition | 2-8°C |
Water Solubility | DMSO: soluble5mg/mL, clear |
RIDADR | NONH for all modes of transport |
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