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  • DC Chemicals Limited
  • China
  • Product Name: UNC-1215
  • Price: $450.0/100mg $900.0/250mg $1800.0/1g
  • Purity: 98.0%
  • Stocking Period: 3 Day
  • Contact: Tony Cao

1415800-43-9

1415800-43-9 structure
1415800-43-9 structure
  • Name: UNC1215
  • Chemical Name: unc1215
  • CAS Number: 1415800-43-9
  • Molecular Formula: C32H43N5O2
  • Molecular Weight: 529.716
  • Catalog: Biochemical Inhibitor Epigenetics Epigenetic Reader Domain Antagonist
  • Create Date: 2017-11-05 23:45:31
  • Modify Date: 2024-01-03 12:14:32
  • UNC1215 is a potent and selective chemical probe for the methyllysine (Kme) reading function of L3MBTL3 with Kd value of 120 nM.IC50 Value: 120 nM (Kd) [1]Target: L3MBTL3 In vitro: UNC1215 binds L3MBTL3 with a K(d) of 120 nM, competitively displacing mono- or dimethyllysine-containing peptides, and is greater than 50-fold more potent toward L3MBTL3 than other members of the MBT family while also demonstrating selectivity against more than 200 other reader domains examined. X-ray crystallography identified a unique 2:2 polyvalent mode of interaction between UNC1215 and L3MBTL3. In cells, UNC1215 is nontoxic and directly binds L3MBTL3 via the Kme-binding pocket of the MBT domains. UNC1215 increases the cellular mobility of GFP-L3MBTL3 fusion proteins, and point mutants that disrupt the Kme-binding function of GFP-L3MBTL3 phenocopy the effects of UNC1215 on localization [1].

Name unc1215
Synonyms (2-Anilino-1,4-phenylene)bis{[4-(1-pyrrolidinyl)-1-piperidinyl]methanone}
Methanone, 1,1'-[2-(phenylamino)-1,4-phenylene]bis[1-[4-(1-pyrrolidinyl)-1-piperidinyl]-
Description UNC1215 is a potent and selective chemical probe for the methyllysine (Kme) reading function of L3MBTL3 with Kd value of 120 nM.IC50 Value: 120 nM (Kd) [1]Target: L3MBTL3 In vitro: UNC1215 binds L3MBTL3 with a K(d) of 120 nM, competitively displacing mono- or dimethyllysine-containing peptides, and is greater than 50-fold more potent toward L3MBTL3 than other members of the MBT family while also demonstrating selectivity against more than 200 other reader domains examined. X-ray crystallography identified a unique 2:2 polyvalent mode of interaction between UNC1215 and L3MBTL3. In cells, UNC1215 is nontoxic and directly binds L3MBTL3 via the Kme-binding pocket of the MBT domains. UNC1215 increases the cellular mobility of GFP-L3MBTL3 fusion proteins, and point mutants that disrupt the Kme-binding function of GFP-L3MBTL3 phenocopy the effects of UNC1215 on localization [1].
Related Catalog
References

[1]. James LI, Barsyte-Lovejoy D, Zhong N, et al. Discovery of a chemical probe for the L3MBTL3 methyllysine reader domain. Nat Chem Biol. 2013 Mar;9(3):184-91. doi: 10.1038/nchembio.1157.

Density 1.2±0.1 g/cm3
Boiling Point 712.1±60.0 °C at 760 mmHg
Molecular Formula C32H43N5O2
Molecular Weight 529.716
Flash Point 384.5±32.9 °C
Exact Mass 529.341675
PSA 59.13000
LogP 3.37
Appearance white to beige
Vapour Pressure 0.0±2.3 mmHg at 25°C
Index of Refraction 1.640
Storage condition 2-8°C
Water Solubility DMSO: soluble5mg/mL, clear
RIDADR NONH for all modes of transport