7-Epitaxol

Modify Date: 2025-08-20 10:05:45

7-Epitaxol Structure
7-Epitaxol structure
Common Name 7-Epitaxol
CAS Number 105454-04-4 Molecular Weight 853.906
Density 1.4±0.1 g/cm3 Boiling Point 957.1±65.0 °C at 760 mmHg
Molecular Formula C47H51NO14 Melting Point 168-170?C
MSDS N/A Flash Point 532.6±34.3 °C

 Use of 7-Epitaxol


7-epi-Taxol is an active metabolite of taxol, with activity comparable to that of taxol against cell replication, promoting microtubule bundle formation and against microtubule depolymerization.

 Names

Name 7-Epitaxol
Synonym More Synonyms

 7-Epitaxol Biological Activity

Description 7-epi-Taxol is an active metabolite of taxol, with activity comparable to that of taxol against cell replication, promoting microtubule bundle formation and against microtubule depolymerization.
Related Catalog
Target

Microtubule/Tubulin[2]

In Vitro 7-epi-Taxol (7-Epitaxol) is a metabolite of taxol[1]. 7-epi-Taxol has activity comparable to that of taxol on cell replication, microtubule bundle formation and in vitro microtubule polymerization[2].
References

[1]. Royer I, et al. Paclitaxel metabolites in human plasma and urine: identification of 6 alpha-hydroxytaxol, 7-epitaxol and taxol hydrolysis products using liquid chromatography/atmospheric-pressure chemical ionization mass spectrometry. Rapid Commun Mass Spectrom. 1995;9(6):495-502.

[2]. Ringel I, et al. Taxol is converted to 7-epitaxol, a biologically active isomer, in cell culture medium. J Pharmacol Exp Ther. 1987 Aug;242(2):692-8.

 Chemical & Physical Properties

Density 1.4±0.1 g/cm3
Boiling Point 957.1±65.0 °C at 760 mmHg
Melting Point 168-170?C
Molecular Formula C47H51NO14
Molecular Weight 853.906
Flash Point 532.6±34.3 °C
Exact Mass 853.330933
PSA 221.29000
LogP 7.38
Vapour Pressure 0.0±0.3 mmHg at 25°C
Index of Refraction 1.637
InChIKey RCINICONZNJXQF-LYTKHFMESA-N
SMILES CC(=O)OC1C(=O)C2(C)C(O)CC3OCC3(OC(C)=O)C2C(OC(=O)c2ccccc2)C2(O)CC(OC(=O)C(O)C(NC(=O)c3ccccc3)c3ccccc3)C(C)=C1C2(C)C
Storage condition -20°C Freezer, Under Inert Atmosphere

 Safety Information

HS Code 2932999026

 Precursor & DownStream

Precursor  0

DownStream  2

 Customs

HS Code 2932999026

 Synonyms

BMS 181339-01
Plaxicel
(2α,5β,7α,10β,13α)-4,10-Diacetoxy-13-{[(2R,3S)-3-(benzoylamino)-2-hydroxy-3-phenylpropanoyl]oxy}-1,7-dihydroxy-9-oxo-5,20-epoxytax-11-en-2-yl benzoate
Paxceed
(2a,5b,7b,10b,13a)-4,10-bis(acetyloxy)-13-{[(2R,3S)-3-(benzoylamino)-2-hydroxy-3-phenylpropanoyl]oxy}-1,7-dihydroxy-9-oxo-5,20-epoxytax-11-en-2-yl benzoate
(2α,5β,7β,10β,13α)-4,10-Diacetoxy-13-{[(2R,3S)-3-(benzoylamino)-2-hydroxy-3-phenylpropanoyl]oxy}-1,7-dihydroxy-9-oxo-5,20-epoxytax-11-en-2-yl benzoate
5b,20-Epoxy-1,2a,4,7b,10b,13a-hexahydroxytax-11-en-9-one 4,10-Diacetate 2-Benzoate 13-Ester with (2R,3S)-N-Benzoyl-3-phenylisoserine
Yewtaxan
Paclitaxel
TaxAlbin
Peclitaxel
Epitaxol
Taxol
(1S,2S,3R,4S,7R,9S,10S,12R,15S)-4,12-Bis(acetyloxy)-1,9-dihydroxy-15-({(2R,3S)-2-hydroxy-3-phenyl-3-[(phenylcarbonyl)amino]propanoyl}oxy)-10,14,17,17-tetramethyl-11-oxo-6-oxatetracyclo[11.3.1.0.0]heptadec-13-en-2-ylbenzolcarboxylat
Paxene
Taxol A
LipoPac
7-Epi Paclitaxel
Ebetaxel
7-epi-Taxol
(2α,5β,7β,10β,13α)-4,10-bis(acetyloxy)-1,7-dihydroxy-13-({(2R,3S)-2-hydroxy-3-phenyl-3-[(phenylcarbonyl)amino]propanoyl}oxy)-9-oxo-5,20-epoxytax-11-en-2-yl benzoate
Anzatax
UNII-P88XT4IS4D
baccatin III N-benzyl-b-phenylisoserine ester
(1S,2S,3R,4S,7R,9S,10S,12R,15S)-4,12-bis(acetyloxy)-1,9-dihydroxy-15-({(2R,3S)-2-hydroxy-3-phenyl-3-[(phenylcarbonyl)amino]propanoyl}oxy)-10,14,17,17-tetramethyl-11-oxo-6-oxatetracyclo[11.3.1.0.0]heptadec-13-en-2-yl benzoate
Onxol
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