Name | CLP 257 | CAS# | 1181081-71-9 | |
---|---|---|---|---|
Price | ¥Inquiry/1g | Purity | 98.9% | |
Stocking Period |
1 Day | Stock | In Stock |
Detail
Product Information
CLP257 (CLP-257) is a potent, selective K+-Cl- cotransporter KCC2 activator with EC50 of 616 nM; displays selectivity for KCC2 over other KCC family members, NKCC1 and GABAA receptors, and a panel of 55 other receptors; restores impaired Cl(-) transport in neurons, rescues KCC2 plasma membrane expression; renormalizes stimulus-evoked responses in spinal nociceptive pathways in a rat model of neuropathic pain. |