CL2-SN-38(DCA)

Published date: 2022-11-29 15:44:27
CL2-SN-38(DCA) Structure
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Name CL2-SN-38 CAS# 1036969-20-6
Price ￥Inquiry/1g Purity 98.9%
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Period		 1 Day Stock In Stock
 Detail Product Information
CL2-SN-38 is a cleavable linker-based antibody-drug conjugate (ADC) containing the topoisomerase I inhibitor SN-38 and a maleimidocaproyl linker. CL2-SN-38 has been linked to tumor-selective human monoclonal antibodies, such as anti-CEACAM5 (hMN-14) to target SN-38 to tumor sites and improve its solubility. CL2-SN-38 linked to hMN-14 binds (Kd = 1.4 nM) and is cytotoxic to LoVo human colon adenocarcinoma cells (IC50 = 5.3 nM). CL2-SN-38 linked to hMN-14 increases survival in a colon carcinoma mouse model of lung metastasis.
Supplier/Manufacture

ShangHai DC Chemicals Co.,Ltd verified supplier

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2024-07-15 CL2-SN-38(DCA)
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2020-12-18 CL2-SN-38(DCA)
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