Carnosol
Carnosol structure
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Common Name | Carnosol | ||
|---|---|---|---|---|
| CAS Number | 5957-80-2 | Molecular Weight | 330.418 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 524.8±50.0 °C at 760 mmHg | |
| Molecular Formula | C20H26O4 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 187.0±23.6 °C | |
Use of CarnosolCarnosol is a potent Ribosomal S6 Kinase (RSK2) inhibitor that could be useful for treating gastric cancer, with an IC50 of ~5.5 μM. |
This table lists Chinese names, IUPAC names and various aliases of this chemical substance.
| Name | carnosol |
|---|---|
| Synonym | More Synonyms |
This table contains bioactivity, target information and biological‑assay experimental data of this compound.
| Description | Carnosol is a potent Ribosomal S6 Kinase (RSK2) inhibitor that could be useful for treating gastric cancer, with an IC50 of ~5.5 μM. |
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| Related Catalog | |
| Target |
IC50: 5.5 μM (RSK2)[1]. |
| In Vitro | It is showed that carnosol has no cytotoxic effects on GES1 cells and 10 μM carnosol strongly suppresses RSK2 activity, but has little effect on any other kinase. Carnosol exerts strong dose-dependent inhibitory effects against RSK2 autophosphorylation and phosphorylation of its substrate ATF1[1]. |
| In Vivo | Results indicate that Carnosol significantly decreaseS the volume and weight of gastric tumors relative to the vehicle-treated group. Additionally, mice tolerate treatment with carnosol without significant loss of body weight similar to the vehicle-treated group. The phosphorylation of CREB, a direct downstream protein of RSK2, Is strongly inhibited in the carnosol-treated group but the expression of total CREB is relatively unchanged[1]. |
| Animal Admin | Mice[1] Mice are orally administrated Carnosol at 100 mg/kg or vehicle 5 times a week over a period of 31 days[1]. |
| References |
This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 524.8±50.0 °C at 760 mmHg |
| Molecular Formula | C20H26O4 |
| Molecular Weight | 330.418 |
| Flash Point | 187.0±23.6 °C |
| Exact Mass | 330.183105 |
| PSA | 66.76000 |
| LogP | 3.71 |
| Vapour Pressure | 0.0±1.4 mmHg at 25°C |
| Index of Refraction | 1.607 |
| InChIKey | XUSYGBPHQBWGAD-PJSUUKDQSA-N |
| SMILES | CC(C)c1cc2c(c(O)c1O)C13CCCC(C)(C)C1CC2OC3=O |
| Storage condition | −20°C |
This table provides MSDS information including hazard classification, first‑aid, fire‑fighting, spill handling, operation and storage instructions.
This table lists upstream starting materials and downstream derivative products related to this chemical.
| Precursor 1 | |
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| DownStream 1 | |
CAS#:3650-09-7
CAS#:80225-53-2This table lists relevant public references with title, journal and publication metadata for this compound.
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Calcium and α-tocopherol suppress cured-meat promotion of chemically induced colon carcinogenesis in rats and reduce associated biomarkers in human volunteers.
Am. J. Clin. Nutr. 98(5) , 1255-62, (2013) Processed meat intake has been associated with increased colorectal cancer risk. We have shown that cured meat promotes carcinogen-induced preneoplastic lesions and increases specific biomarkers in th... |
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Degradation study of carnosic acid, carnosol, rosmarinic acid, and rosemary extract (Rosmarinus officinalis L.) assessed using HPLC.
J. Agric. Food Chem. 60(36) , 9305-14, (2012) Rosemary, whose major caffeoyl-derived and diterpenoid ingredients are rosmarinic acid, carnosol, and carnosic acid, is an important source of natural antioxidants and is being recognized increasingly... |
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Relevance of carnosic acid, carnosol, and rosmarinic acid concentrations in the in vitro antioxidant and antimicrobial activities of Rosmarinus officinalis (L.) methanolic extracts.
J. Agric. Food Chem. 60(38) , 9603-8, (2012) The importance of the diterpenic and rosmarinic acid content in the biological activities of rosemary extracts has been studied previously, but how the relationship between the concentration of these ... |
This table contains target information, in‑vitro & in‑vivo assay data for this compound.
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Name: USP8 deubiquitinase inhibition: Primary qHTS
Source: 24642
Target: ubiquitin specific peptidase 8
External Id: USP8 FAST DUB HTS Primary
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Name: Antibiofilm activity against Pseudomonas aeruginosa ATCC 50071 assessed as inhibition...
Source: ChEMBL
Target: Pseudomonas aeruginosa
External Id: CHEMBL4814885
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Name: Antibiofilm activity against Staphylococcus aureus ATCC 25923 assessed as inhibition ...
Source: ChEMBL
Target: Staphylococcus aureus
External Id: CHEMBL4814886
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Name: Inhibition of pancreatic lipase
Source: ChEMBL
Target: Pancreatic triacylglycerol lipase
External Id: CHEMBL925170
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Name: USP17 deubiquitinase inhibition: Primary qHTS
Source: 24642
Target: ubiquitin specific peptidase 17 like family member 5
External Id: USP17 FAST DUB HTS Primary
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Name: USP7 deubiquitinase inhibition: Primary qHTS
Source: 24642
Target: ubiquitin specific peptidase 7
External Id: USP7 FAST DUB HTS Primary
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Name: Antibiofilm activity against Listeria monocytogenes ATCC 7644 assessed as inhibition ...
Source: ChEMBL
Target: Listeria monocytogenes
External Id: CHEMBL4814884
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Name: Inhibition of microsomal PGES1 in ILbeta-stimulated human A549 cells using PGH2 as su...
Source: ChEMBL
Target: Prostaglandin E synthase
External Id: CHEMBL3772154
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Name: Inhibition of human N-terminal TEV protease cleavage site-fused-His6-tagged FPPS expr...
Source: ChEMBL
Target: Farnesyl pyrophosphate synthase
External Id: CHEMBL4417107
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This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.
| (7β)-11,12-Dihydroxy-7,20-epoxyabieta-8,11,13-trien-20-one |
| (7β)-11,12-Dihydroxy-7,20-epoxyabieta-8(14),9(11),12-trien-20-one |
| Carnosol |
This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.
| Q: What English synonyms does carnosol have? |
| A: English synonyms of carnosol: (7β)-11,12-Dihydroxy-7,20-epoxyabieta-8,11,13-trien-20-one, (7β)-11,12-Dihydroxy-7,20-epoxyabieta-8(14),9(11),12-trien-20-one, Carnosol. |
| Q: What is the safety information for carnosol? |
| A: Safety information for carnosol: 24/25. |
| Q: What is the boiling point of carnosol? |
| A: Boiling point of carnosol is 524.8±50.0 °C at 760 mmHg. |
| Q: What is the CAS number of carnosol? |
| A: CAS number of carnosol is 5957-80-2. |
| Q: What are the downstream products of carnosol? |
| A: Related downstream products(CAS) of carnosol: 80225-53-2. |
| Q: What is the molecular weight of carnosol? |
| A: Molecular weight of carnosol is 330.418. |
| Q: What is the molecular formula of carnosol? |
| A: Molecular formula of carnosol is C20H26O4. |
| Q: What is the polar surface area (PSA) of carnosol? |
| A: Polar surface area (PSA) of carnosol is 66.76000. |
| Q: What are the storage conditions for carnosol? |
| A: Storage conditions for carnosol: −20°C. |
| Q: What are the upstream materials of carnosol? |
| A: Related upstream materials(CAS) of carnosol: 3650-09-7. |
This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.
| Shanghai Nianxing Industrial Co., Ltd |
| BioBioPha |
| naturewill |