Deoxyshikonin

Modify Date: 2025-08-24 21:15:48

Deoxyshikonin structure	Common Name	Deoxyshikonin
	CAS Number	43043-74-9	Molecular Weight	272.296
	Density	1.3±0.1 g/cm3	Boiling Point	503.7±50.0 °C at 760 mmHg
	Molecular Formula	C₁₆H₁₆O₄	Melting Point	91ºC
	MSDS	N/A	Flash Point	272.5±26.6 °C

Use of Deoxyshikonin

Deoxyshikonin is isolated from Lithospermum erythrorhizon Sieb with antitumor activity. Deoxyshikonin increases the expression of VEGF-C and VEGF-A mRNA in HMVEC-dLy, promotes HIF-1α and HIF-1β subunit interaction and binds to specific DNA sequences targeted by HIF, indicates a prolymphangiogenesis as well as a proangiogenesis effect in vitro[1]. Deoxyshikonin shows significant synergic antimicrobial activity with tetracycline against S. pneumonia (MIC=17 μg/mL), also shows significantly inhibitory activities against MRSA[2].

Name	5,8-dihydroxy-2-(4-methylpent-3-enyl)naphthalene-1,4-dione
Synonym	More Synonyms

Description	Deoxyshikonin is isolated from Lithospermum erythrorhizon Sieb with antitumor activity. Deoxyshikonin increases the expression of VEGF-C and VEGF-A mRNA in HMVEC-dLy, promotes HIF-1α and HIF-1β subunit interaction and binds to specific DNA sequences targeted by HIF, indicates a prolymphangiogenesis as well as a proangiogenesis effect in vitro[1]. Deoxyshikonin shows significant synergic antimicrobial activity with tetracycline against S. pneumonia (MIC=17 μg/mL), also shows significantly inhibitory activities against MRSA[2].
Related Catalog	Research Areas >> Cancer Research Areas >> Cardiovascular Disease Research Areas >> Infection Signaling Pathways >> Metabolic Enzyme/Protease >> HIF/HIF Prolyl-Hydroxylase Signaling Pathways >> Anti-infection >> Bacterial
References	[1]. Prangsaengtong O, et al. Enhancement of Lymphangiogenesis In Vitro via the Regulations of HIF-1α Expression and Nuclear Translocation by Deoxyshikonin. Evid Based Complement Alternat Med. 2013;2013:148297. [2]. Zhang S, et al. Antibacterial effects of Traditional Chinese Medicine monomers against Streptococcus pneumoniae via inhibiting pneumococcal histidine kinase (VicK). Front Microbiol. 2015 May 20;6:479.

Description

Related Catalog

Research Areas >> Cancer

Research Areas >> Cardiovascular Disease

Research Areas >> Infection

Signaling Pathways >> Metabolic Enzyme/Protease >> HIF/HIF Prolyl-Hydroxylase

Signaling Pathways >> Anti-infection >> Bacterial

References

[1]. Prangsaengtong O, et al. Enhancement of Lymphangiogenesis In Vitro via the Regulations of HIF-1α Expression and Nuclear Translocation by Deoxyshikonin. Evid Based Complement Alternat Med. 2013;2013:148297.

[2]. Zhang S, et al. Antibacterial effects of Traditional Chinese Medicine monomers against Streptococcus pneumoniae via inhibiting pneumococcal histidine kinase (VicK). Front Microbiol. 2015 May 20;6:479.

Density	1.3±0.1 g/cm3
Boiling Point	503.7±50.0 °C at 760 mmHg
Melting Point	91ºC
Molecular Formula	C₁₆H₁₆O₄
Molecular Weight	272.296
Flash Point	272.5±26.6 °C
Exact Mass	272.104858
PSA	74.60000
LogP	4.72
Vapour Pressure	0.0±1.3 mmHg at 25°C
Index of Refraction	1.611
InChIKey	VOMDIEGPEURZJO-UHFFFAOYSA-N
SMILES	CC(C)=CCCC1=CC(=O)c2c(O)ccc(O)c2C1=O
Storage condition	2-8C

Deoxyshikonin MSDS(Chinese)

Safety Phrases	22-24/25
HS Code	2914690090

Precursor 0
DownStream 1
CAS#:517-90-8 5,8-dihydroxy-2...

HS Code	2914690090
Summary	2914690090 other quinones。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%

Name: Cell-based high throughput primary assay to identify activators of GPR151
Source: The Scripps Research Institute Molecular Screening Center
Target: RecName: Full=G-protein coupled receptor 151; AltName: Full=G-protein coupled receptor PGR7; AltName: Full=GPCR-2037; AltName: Full=Galanin receptor 4; AltName: Full=Galanin-receptor-like protein; Short=GalRL
External Id: GPR151_PHUNTER_AG_LUMI_1536_1X%ACT

Name: AlphaScreen-based biochemical high throughput primary assay to identify activators of...
Source: The Scripps Research Institute Molecular Screening Center
Target: N/A
External Id: FBW7_ACT_ALPHA_1536_1X%ACT PRUN

Name: AlphaScreen-based biochemical high throughput primary assay to identify inhibitors of...
Source: The Scripps Research Institute Molecular Screening Center
External Id: MITF_INH_Alpha_1536_1X%INH PRUN

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1'O-deoxyshikonin

ARNEBIN-7

5,8-Dihydroxy-2-(4-methyl-3-penten-1-yl)-1,4-naphthoquinone

deoxyalkannin

5,8-Dihydroxy-2-(4-methyl-3-pentenyl)-1,4-naphthalenedione

11-Deoxyalkannin

5,8-Dihydroxy-2-(4-methyl-pent-3-enyl)-1,4-naphthoquinone

5,8-Dihydroxy-2-(4-methyl-3-pentenyl)naphthoquinone

deoxyshikonin

5,8-Dihydroxy-2-(4-methylpent-3-en-1-yl)-1,4-naphthoquinone

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Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Deoxyshikonin
Price: ￥1478.0/20mg
Purity: 98.0%
Delivery: 1 Day
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