1,3-Diphenylguanidine

Modify Date: 2025-08-22 08:55:04

1,3-Diphenylguanidine structure	Common Name	1,3-Diphenylguanidine
	CAS Number	102-06-7	Molecular Weight	211.262
	Density	1.1±0.1 g/cm3	Boiling Point	321.3±25.0 °C at 760 mmHg
	Molecular Formula	C₁₃H₁₃N₃	Melting Point	146-148 °C(lit.)
	MSDS	Chinese USA	Flash Point	148.1±23.2 °C
	Symbol	GHS06, GHS08, GHS09	Signal Word	Danger

Use of 1,3-Diphenylguanidine

1,3-diphenylguanidine is the primary and secondary accelerator in the vulcanization of rubber and is found in the rubber industry[1].

Name	1,3-Diphenylguanidine
Synonym	More Synonyms

Description	1,3-diphenylguanidine is the primary and secondary accelerator in the vulcanization of rubber and is found in the rubber industry[1].
Related Catalog	Research Areas >> Others Signaling Pathways >> Others >> Others

Density	1.1±0.1 g/cm3
Boiling Point	321.3±25.0 °C at 760 mmHg
Melting Point	146-148 °C(lit.)
Molecular Formula	C₁₃H₁₃N₃
Molecular Weight	211.262
Flash Point	148.1±23.2 °C
Exact Mass	211.110947
PSA	47.91000
LogP	2.36
Vapour Pressure	0.0±0.7 mmHg at 25°C
Index of Refraction	1.600
InChIKey	OWRCNXZUPFZXOS-UHFFFAOYSA-N
SMILES	NC(=Nc1ccccc1)Nc1ccccc1
Stability	Stable. Combustible. Incompatible with strong oxidizing agents. Moisture sensitive.
Water Solubility	slightly soluble

1,3-Diphenylguanidine MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: MF0875000

CHEMICAL NAME :: Guanidine, 1,3-diphenyl-

CAS REGISTRY NUMBER :: 102-06-7

LAST UPDATED :: 199712

DATA ITEMS CITED :: 29

MOLECULAR FORMULA :: C13-H13-N3

MOLECULAR WEIGHT :: 211.29

WISWESSER LINE NOTATION :: MUYMR&MR

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 323 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 75 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 323 mg/kg

TOXIC EFFECTS :: Blood - normocytic anemia

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 150 mg/kg

TOXIC EFFECTS :: Peripheral Nerve and Sensation - flaccid paralysis without anesthesia (usually neuromuscular blockage) Behavioral - ataxia

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 25 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 258 mg/kg

TOXIC EFFECTS :: Blood - normocytic anemia

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 25 mg/kg

TOXIC EFFECTS :: Behavioral - altered sleep time (including change in righting reflex) Behavioral - tetany

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 250 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: >794 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 246 mg/kg

TOXIC EFFECTS :: Blood - normocytic anemia

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 250 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 200 mg/kg

TOXIC EFFECTS :: Behavioral - altered sleep time (including change in righting reflex) Behavioral - tetany

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - species unspecified

DOSE/DURATION :: 250 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Behavioral - muscle contraction or spasticity Lungs, Thorax, or Respiration - dyspnea

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 3808 mg/kg/17W-I

TOXIC EFFECTS :: Blood - pigmented or nucleated red blood cells Blood - changes in erythrocyte (RBC) count Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - catalases

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 76 mg/kg

SEX/DURATION :: female 1-19 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - musculoskeletal system

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 190 mg/kg

SEX/DURATION :: female 1-19 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - pre-implantation mortality (e.g. reduction in number of implants per female; total number of implants per corpora lutea)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 56 mg/kg

SEX/DURATION :: male 7 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Fertility - male fertility index (e.g. # males impregnating females per # males exposed to fertile nonpregnant females) Reproductive - Fertility - pre-implantation mortality (e.g. reduction in number of implants per female; total number of implants per corpora lutea)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 196 mg/kg

SEX/DURATION :: male 49 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 140 mg/kg

SEX/DURATION :: male 35 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - testes, epididymis, sperm duct

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 224 mg/kg

SEX/DURATION :: male 56 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count)

MUTATION DATA

TYPE OF TEST :: Body fluid assay

TEST SYSTEM :: Rodent - mouse Bacteria - Salmonella typhimurium

DOSE/DURATION :: 36 ng/kg

REFERENCE :: JEPOEC Journal of Environmental Pathology, Toxicology and Oncology. (Chem-Orbital, POB 134, Park Forest, IL 60466) V.5(4)- 1984- Volume(issue)/page/year: 6(1-2),293,1985 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 27760 No. of Facilities: 326 (estimated) No. of Industries: 10 No. of Occupations: 21 No. of Employees: 14344 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 27760 No. of Facilities: 874 (estimated) No. of Industries: 14 No. of Occupations: 40 No. of Employees: 28146 (estimated) No. of Female Employees: 4339 (estimated)

Symbol	GHS06, GHS08, GHS09
Signal Word	Danger
Hazard Statements	H301-H315-H319-H335-H361f-H411
Precautionary Statements	P261-P273-P281-P301 + P310-P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Faceshields;Gloves
Hazard Codes	Xn:Harmful
Risk Phrases	R22;R36/37/38;R51/53;R62
Safety Phrases	S26-S36/37/39-S61
RIDADR	UN 3077 9/PG 3
WGK Germany	2
RTECS	MF0875000
Packaging Group	III
Hazard Class	9
HS Code	29252000

Precursor 8
CAS#:102-08-9 Thiocarbanilide CAS#:591-50-4 Iodobenzene CAS#:506-93-4 Guanidine nitrate CAS#:108-86-1 Bromobenzene
CAS#:123564-74-9 N'-phenylimidaz... CAS#:103-85-5 Phenylthiocarbamide CAS#:25343-52-6 Phenylimino(ami... CAS#:506-77-4 Cyanogen chloride
DownStream 9
CAS#:580-35-8 Pyridine,2,4,6-... CAS#:25506-69-8 1,2,4,6-tetraph... CAS#:102-08-9 Thiocarbanilide CAS#:24577-43-3 bis[N,N'-diphen...
CAS#:103-84-4 Acetanilide CAS#:4664-01-1 Pyrrolo[3,4-c]p... CAS#:65252-12-2 2-carboxybenzen... CAS#:76240-10-3 (4S,5S)-4-(3,4,...
CAS#:101-01-9 1,2,3-Triphenyl...

HS Code	29252000

Occupational allergic contact dermatitis and patch test results of leather workers at two Indonesian tanneries.

Contact Dermatitis 67(5) , 277-83, (2012)

Tannery workers are at considerable risk of developing occupational contact dermatitis. Occupational skin diseases in tannery workers in newly industrialized countries have been reported, but neither ...

Allergic contact dermatitis to synthetic rubber gloves: changing trends in patch test reactions to accelerators.

Arch. Dermatol. 146(9) , 1001-7, (2010)

Rubber gloves are one of the most frequent causes of occupational allergic contact dermatitis, especially in health care workers.We describe 23 patients with allergic contact dermatitis due to rubber ...

Identification of unexpected modifications of fluorescein-labeled oligodeoxynucleotides by nuclease P1 digestion and mass spectrometric techniques.

Rapid Commun. Mass Spectrom. 14(1) , 26-32, (2000)

Fluorescein-labeled oligodeoxynucleotides (ODNs) from automated synthesis commonly produce multiple peaks in high performance liquid chromatography (HPLC) chromatograms. We found that these peaks are ...

Name: Primary qHTS assay for inhibitors of alpha-synuclein gene (SNCA) expression
Source: NCGC
External Id: SNCA-p-activity-luciferase

Name: Fluorescence-based cell-based primary high throughput screening assay to identify ago...
Source: The Scripps Research Institute Molecular Screening Center
Target: muscarinic acetylcholine receptor M1 [Homo sapiens]
External Id: CHRM1_AG_FLUO8_1536_1X%ACT PRUN

Name: Cytochrome P450 Family 1 Subfamily A Member 2 (CYP1A2) small molecule antagonists: lu...
Source: 824
External Id: CYP273

Name: Fluorescence-based cell-based primary high throughput screening assay to identify pos...
Source: The Scripps Research Institute Molecular Screening Center
Target: muscarinic acetylcholine receptor M1 [Homo sapiens]
External Id: CHRM1_PAM_FLUO8_1536_1X%ACT PRUN

Name: qHTS Assay for Small Molecule Inhibitors of the Human hERG Channel Activity
Source: NCGC
External Id: HERG01

Name: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen
Source: NCGC
Target: N/A
External Id: SMAD3201

Name: uHTS identification of cystic fibrosis induced NFkb Inhibitors in a fluoresence assay
Source: Burnham Center for Chemical Genomics
Target: cystic fibrosis transmembrane conductance regulator [Homo sapiens]
External Id: SBCCG-A764-CF-PAF-Primary-Assay

Name: Alphascreen assay for small molecules abrogating mHTT-CaM Interaction
Source: 24983
Target: Huntingtin
External Id: KUHTS-Muma KU-CaM-Htt INH-01

Name: Fluorescence-based cell-based primary high throughput screening assay to identify ant...
Source: The Scripps Research Institute Molecular Screening Center
Target: muscarinic acetylcholine receptor M1 [Homo sapiens]
External Id: CHRM1_ANT_FLUO8_1536_1X%INH PRUN

Name: qHTS for Inhibitors of TGF-b
Source: NCGC
Target: Smad3 [Homo sapiens]
External Id: SMAD3101

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China
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China
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1,3-Diphenylguanidine

Use of 1,3-Diphenylguanidine

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