Pyronaridine-d4 tetraphosphate

Modify Date: 2024-01-04 01:39:49

Pyronaridine-d4 tetraphosphate structure	Common Name	Pyronaridine-d4 tetraphosphate
	CAS Number	1186026-25-4	Molecular Weight	914.06
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₉H₄₀D₄ClN₅O₁₈P₄	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Pyronaridine-d4 tetraphosphate

Pyronaridine-d4 (tetraphosphate) is the deuterium labeled Pyronaridine tetraphosphate[1]. Pyronaridine tetraphosphate is an orally active Mannich base anti-malarial agent. Pyronaridine tetraphosphate is active against P. falciparum and Echinococcus granulosus infection[2][3].

Name	Pyronaridine-d4 tetraphosphate

Description	Pyronaridine-d4 (tetraphosphate) is the deuterium labeled Pyronaridine tetraphosphate[1]. Pyronaridine tetraphosphate is an orally active Mannich base anti-malarial agent. Pyronaridine tetraphosphate is active against P. falciparum and Echinococcus granulosus infection[2][3].
Related Catalog	Research Areas >> Infection
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [2]. Vivas L, et al. Anti-malarial efficacy of pyronaridine and artesunate in combination in vitro and in vivo. Acta Trop. 2008 Mar;105(3):222-8. [3]. Jun Li, et al. Old drug repurposing for neglected disease: Pyronaridine as a promising candidate for the treatment of Echinococcus granulosus infections. EBioMedicine. 2020 Apr;54:102711.

Molecular Formula	C₂₉H₄₀D₄ClN₅O₁₈P₄
Molecular Weight	914.06

Pyronaridine-d4 tetraphosphate

Use of Pyronaridine-d4 tetraphosphate

Names

Pyronaridine-d4 tetraphosphate Biological Activity

Chemical & Physical Properties