Olopatadine-d6

Modify Date: 2024-04-11 10:07:06

Olopatadine-d6 Structure
Olopatadine-d6 structure
Common Name Olopatadine-d6
CAS Number 1231979-85-3 Molecular Weight 343.45
Density N/A Boiling Point N/A
Molecular Formula C21H17D6NO3 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Olopatadine-d6


Olopatadine-d6 is the deuterium labeled Olopatadine[1]. Olopatadine is an orally active and selective histamine 1 (H1) receptor antagonist and a mast cell stabilizer. Olopatadine prevents immunologically stimulated pro-inflammatory mediator release from human conjunctival mast cells. Olopatadine can be used for researching allergic conjunctivitis[2][3].

 Names

Name Olopatadine-d6

 Olopatadine-d6 Biological Activity

Description Olopatadine-d6 is the deuterium labeled Olopatadine[1]. Olopatadine is an orally active and selective histamine 1 (H1) receptor antagonist and a mast cell stabilizer. Olopatadine prevents immunologically stimulated pro-inflammatory mediator release from human conjunctival mast cells. Olopatadine can be used for researching allergic conjunctivitis[2][3].
Related Catalog
In Vitro Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.  

[2]. Kam KW, et al. Topical Olopatadine in the Treatment of Allergic Conjunctivitis: A Systematic Review and Meta-analysis. Ocul Immunol Inflamm. 2017 Oct;25(5):663-677.  

[3]. Leonardi A, et al. Olopatadine: a drug for allergic conjunctivitis targeting the mast cell. Expert Opin Pharmacother. 2010 Apr11(6):969-81.  

 Chemical & Physical Properties

Molecular Formula C21H17D6NO3
Molecular Weight 343.45