Amylin (rat)

Modify Date: 2024-01-08 08:21:34

Amylin (rat) structure	Common Name	Amylin (rat)
	CAS Number	124447-81-0	Molecular Weight	3920.44
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₆₇H₂₇₂N₅₂O₅₃S₂	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Amylin (rat)

Amylin, amide, rat is a potent and high affinity ligand of Amylin receptor AMY1 and AMY3 receptors and variably of AMY2 receptors; binding studies are generally used for the latter receptor.

Name	Amylin, amide, rat

Description	Amylin, amide, rat is a potent and high affinity ligand of Amylin receptor AMY1 and AMY3 receptors and variably of AMY2 receptors; binding studies are generally used for the latter receptor.
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Metabolic Disease Peptides
Target	Amylin receptor AMY1 and AMY3[1]
In Vitro	Amylin is an important, but poorly understood, 37 amino acid glucoregulatory hormone with great potential to target metabolic diseases. Amylin is a member of the calcitonin (CT) family of peptides, which includes CT itself, the CGRPs comprising two variants (αCGRP and βCGRP), adrenomedullin (AM) and AM2 (intermedin). Amylin is a centrally acting, neuroendocrine hormone synthesized with insulin in the beta cells of pancreatic islets. Amylin regulates glucose homeostasis by inhibiting gastric emptying, inhibiting the release of the counter-regulatory hormone glucagon and inducing meal-ending satiety. Amylin functions as a glucoregulatory and satiety-inducing hormone, which is protective against postprandial spikes in blood glucose and overeating.[1]
References	[1]. Bower RL, et al. Amylin structure-function relationships and receptor pharmacology: implications for Amylin mimetic drug development. Br J Pharmacol. 2016 Jun;173(12):1883-98.

Molecular Formula	C₁₆₇H₂₇₂N₅₂O₅₃S₂
Molecular Weight	3920.44
Storage condition	2-8℃