MK-8768

Modify Date: 2024-01-30 18:01:31

MK-8768 structure	Common Name	MK-8768
	CAS Number	1432729-22-0	Molecular Weight	433.43
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₁H₂₂F₃N₅O₂	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of MK-8768

MK-8768 is a highly potent, orally bioavailable and selective class of mGluR2 negative allosteric modulator (IC50 of 9 .6nM) with excellent brain permeability.

Name	MK-8768

Description	MK-8768 is a highly potent, orally bioavailable and selective class of mGluR2 negative allosteric modulator (IC50 of 9 .6nM) with excellent brain permeability.
Related Catalog	Signaling Pathways >> GPCR/G Protein >> mGluR Research Areas >> Metabolic Disease
Target	IC50:9.6 nM(mGluR2)[1]
References	[1]. Michael T. Rudd, et al. Discovery of MK-8768, a Potent and Selective mGluR2 Negative Allosteric Modulator. ACS Med. Chem. Lett.. 2023，14，8. [2]. Sean M Smith, et al. The novel phosphodiesterase 10A inhibitor THPP-1 has antipsychotic-like effects in rat and improves cognition in rat and rhesus monkey.Neuropharmacology, 2013 Jan;64:215-23.

Molecular Formula	C₂₁H₂₂F₃N₅O₂
Molecular Weight	433.43

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MK-8768

Use of MK-8768

Names

MK-8768 Biological Activity

Chemical & Physical Properties