Shanghai Nianxing Industrial Co., Ltd
China
Product Name: MK-8768
Price: Check
Purity: 98.0%
Stocking Period: 10 Day
Contact: Yang
Email: sales@echemcloud.com

DC Chemicals Limited
China
Product Name: MK-8768
Price: ￥Inquiry/100mg ￥Inquiry/250mg ￥Inquiry/1g
Purity: 98.0%
Stocking Period: 10 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

1432729-22-0

1432729-22-0 structure

1432729-22-0 structure

Name: MK-8768
Chemical Name: MK-8768
CAS Number: 1432729-22-0
Molecular Formula: C₂₁H₂₂F₃N₅O₂
Molecular Weight: 433.43
Catalog: Signaling Pathways GPCR/G Protein mGluR
Create Date: 2023-10-20 21:20:07
Modify Date: 2024-01-30 18:01:31
MK-8768 is a highly potent, orally bioavailable and selective class of mGluR2 negative allosteric modulator (IC50 of 9 .6nM) with excellent brain permeability.

Name	MK-8768

Description	MK-8768 is a highly potent, orally bioavailable and selective class of mGluR2 negative allosteric modulator (IC50 of 9 .6nM) with excellent brain permeability.
Related Catalog	Signaling Pathways >> GPCR/G Protein >> mGluR Research Areas >> Metabolic Disease
Target	IC50:9.6 nM(mGluR2)[1]
References	[1]. Michael T. Rudd, et al. Discovery of MK-8768, a Potent and Selective mGluR2 Negative Allosteric Modulator. ACS Med. Chem. Lett.. 2023，14，8. [2]. Sean M Smith, et al. The novel phosphodiesterase 10A inhibitor THPP-1 has antipsychotic-like effects in rat and improves cognition in rat and rhesus monkey.Neuropharmacology, 2013 Jan;64:215-23.

Molecular Formula	C₂₁H₂₂F₃N₅O₂
Molecular Weight	433.43

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