MTX115325
Modify Date: 2024-01-03 10:59:28
MTX115325 structure
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Common Name | MTX115325 | ||
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| CAS Number | 2750895-97-5 | Molecular Weight | 348.36 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C18H16N6O2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of MTX115325MTX115325 (Example 1) is an orally active, brain-penetrating USP30 inhibitor (IC50=12 nM) with neuroprotective activity. MTX115325 increases ubiquitination (EC50=32 nM) of the mitochondrial outer membrane protein TOM20 (a USP30 substrate), increasing mitophagy. MTX115325 prevents dopaminergic neuron loss and preserves striatal dopamine[1]. |
| Name | MTX115325 |
|---|
| Description | MTX115325 (Example 1) is an orally active, brain-penetrating USP30 inhibitor (IC50=12 nM) with neuroprotective activity. MTX115325 increases ubiquitination (EC50=32 nM) of the mitochondrial outer membrane protein TOM20 (a USP30 substrate), increasing mitophagy. MTX115325 prevents dopaminergic neuron loss and preserves striatal dopamine[1]. |
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| Related Catalog | |
| Target |
IC50: 12 nM (USP30) EC50: 32 nM (TOM20, the outer mitochondrial membrane protein)[1] |
| References |
| Molecular Formula | C18H16N6O2 |
|---|---|
| Molecular Weight | 348.36 |