Triamcinolone acetonide-d6

Modify Date: 2024-01-02 17:27:02

Triamcinolone acetonide-d6 Structure
Triamcinolone acetonide-d6 structure
Common Name Triamcinolone acetonide-d6
CAS Number 352431-33-5 Molecular Weight 440.53
Density 1.3±0.1 g/cm3 Boiling Point 576.9±50.0 °C at 760 mmHg
Molecular Formula C24H25D6FO6 Melting Point N/A
MSDS N/A Flash Point 302.7±30.1 °C

 Use of Triamcinolone acetonide-d6


Triamcinolone acetonide-d6 is deuterium labeled Triamcinolone acetonide.

 Names

Name (4aS,4bR,5S,6aS,6bS,9aR,10aS,10bS)-4b-Fluoro-6b-glycoloyl-5-hydroxy-4a,6a-dimethyl-8,8-bis[(2H3)methyl]-4a,4b,5,6,6a,6b,9a,10,10a,10b,11,12-dodecahydro-2H-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol-2-one
Synonym More Synonyms

 Triamcinolone acetonide-d6 Biological Activity

Description Triamcinolone acetonide-d6 is deuterium labeled Triamcinolone acetonide.
Related Catalog
In Vitro Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References

[1]. http://en.wikipedia.org/wiki/Triamcinolone_acetonide

[2]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

[3]. Zhen Xiang, et al. Glucocorticoids improve severe or critical COVID-19 by activating ACE2 and reducing IL-6 levels. Int J Biol Sci 2020; 16(13):2382-2391.

 Chemical & Physical Properties

Density 1.3±0.1 g/cm3
Boiling Point 576.9±50.0 °C at 760 mmHg
Molecular Formula C24H25D6FO6
Molecular Weight 440.53
Flash Point 302.7±30.1 °C
Exact Mass 440.248138
LogP 2.50
Vapour Pressure 0.0±3.6 mmHg at 25°C
Index of Refraction 1.589

 Synonyms

(4aS,4bR,5S,6aS,6bS,9aR,10aS,10bS)-4b-Fluoro-6b-glycoloyl-5-hydroxy-4a,6a-dimethyl-8,8-bis[(2H3)methyl]-4a,4b,5,6,6a,6b,9a,10,10a,10b,11,12-dodecahydro-2H-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxo l-2-one
2H-Naphth[2',1':4,5]indeno[1,2-d][1,3]dioxol-2-one, 4b-fluoro-4a,4b,5,6,6a,6b,9a,10,10a,10b,11,12-dodecahydro-5-hydroxy-6b-(2-hydroxyacetyl)-4a,6a-dimethyl-8,8-di(methyl-d3)-, (4aS,4bR,5S,6aS,6bS,9a R,10aS,10bS)-