PM050489
Modify Date: 2024-04-08 14:17:57
PM050489 structure
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Common Name | PM050489 | ||
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| CAS Number | 960210-97-3 | Molecular Weight | 606.15 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C31H44ClN3O7 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of PM050489PM050489 is an effective polyketone inhibitor of Microtubule/Tubulin that can be isolated from Madagascan sponge Lithoplocamia lithistoides. PM050489 inhibits mitosis with an IC50 value of 26.4 nM. PM050489 has antitumor activity and can be used in cancer research[1][2]. |
| Name | PM050489 |
|---|
| Description | PM050489 is an effective polyketone inhibitor of Microtubule/Tubulin that can be isolated from Madagascan sponge Lithoplocamia lithistoides. PM050489 inhibits mitosis with an IC50 value of 26.4 nM. PM050489 has antitumor activity and can be used in cancer research[1][2]. |
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| Related Catalog | |
| Target |
Mitosis[1] |
| In Vitro | PM050489 抑制 HT-29、A-549 和 MDA-MB-231 细胞的活力，GI50 分别为 0.46 nM、0.38 nM 和 0.45 nM[1]。 PM050489 (0.01 nM 和 0.1 nM；24 h) 破坏 A549 细胞中微管网络和有丝分裂纺锤体的形态[2]。 PM050489 (0.01、0.1、1 和 10 nM) 以剂量依赖性方式在 A549 细胞中抑制微管蛋白的聚合[2]。 Cell Cycle Analysis[2] Cell Line: A549 cells. Concentration: 0.25 nM. Incubation Time: 20 h. Result: Induced A549 cell cycle arrest in G2/M phase. |
| References |
| Molecular Formula | C31H44ClN3O7 |
|---|---|
| Molecular Weight | 606.15 |