Succinic acid

Names

[ CAS No. ]:
110-15-6

[ Name ]:
Succinic acid

[Synonym ]:
MFCD00002789
Butane diacid
Butanedioic acid,natural
HOOC-CH2-CH2-COOH
4-02-00-01908 (Beilstein Handbook Reference)
Bernsteinsaure [German]
Succinic acid
1,4-Butanedioic acid
1,2-Ethanedicarboxylic acid
Sal succini
QV2VQ
Succinic acid
Butanedioic acid
Asuccin
Katasuccin
Wormwood
EINECS 203-740-4
spirit of amber
AMBER ACID

Biological Activity

[Description]:

Succinic acid is an intermediate product of the tricarboxylic acid cycle, as well as one of fermentation products of anaerobic metabolism.

[Related Catalog]:

Natural Products >> Acids and Aldehydes

Research Areas >> Metabolic Disease

[Target]

Human Endogenous Metabolite

[References]

[1]. Zhang YJ, et al. Optimization of succinic acid fermentation with Actinobacillus succinogenes by response surface methodology (RSM). J Zhejiang Univ Sci B. 2012 Feb;13(2):103-10.

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
236.1±13.0 °C at 760 mmHg

[ Melting Point ]:
185 °C

[ Molecular Formula ]:
C₄H₆O₄

[ Molecular Weight ]:
118.088

[ Flash Point ]:
110.9±16.3 °C

[ Exact Mass ]:
118.026611

[ PSA ]:
74.60000

[ LogP ]:
-0.59

[ Vapour Pressure ]:
0.0±1.0 mmHg at 25°C

[ Index of Refraction ]:
1.478

[ Storage condition ]:
Store at RT.

[ Stability ]:
Stable. Substances to be avoided include strong bases, strong oxidizing agents. Combustible.

[ Water Solubility ]:
80 g/L (20 ºC)

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: WM4900000

CHEMICAL NAME :: Succinic acid

CAS REGISTRY NUMBER :: 110-15-6

BEILSTEIN REFERENCE NO. :: 1754069

LAST UPDATED :: 199701

DATA ITEMS CITED :: 8

MOLECULAR FORMULA :: C4-H6-O4

MOLECULAR WEIGHT :: 118.10

WISWESSER LINE NOTATION :: QV2VQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2260 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2702 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1400 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :: DNA inhibition

TEST SYSTEM :: Human Fibroblast

DOSE/DURATION :: 20 mmol/L

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 183,89,1987 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 84381 No. of Facilities: 316 (estimated) No. of Industries: 18 No. of Occupations: 21 No. of Employees: 3351 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 84381 No. of Facilities: 1652 (estimated) No. of Industries: 16 No. of Occupations: 38 No. of Employees: 31198 (estimated) No. of Female Employees: 16182 (estimated)

Safety Information

[ Symbol ]:

GHS05

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H318

[ Precautionary Statements ]:
P280-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi:Irritant

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S36/37/39-S37/39

[ RIDADR ]:
UN 3265 8/PG 3

[ WGK Germany ]:
1

[ RTECS ]:
WM4900000

[ Hazard Class ]:
8.0

[ HS Code ]:
2917190090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2917190090

[ Summary ]:
2917190090 acyclic polycarboxylic acids, their anhydrides, halides, peroxides, peroxyacids and their derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

Articles

Urinary metabolic fingerprinting of mice with diet-induced metabolic derangements by parallel dual secondary column-dual detection two-dimensional comprehensive gas chromatography.

J. Chromatogr. A. 1361 , 265-76, (2014)

This study investigates the potential of a parallel dual secondary column-dual detection two-dimensional comprehensive GC platform (GC×2GC-MS/FID) for metabolic profiling and fingerprinting of mouse u...

Direct silylation of Trypanosoma brucei metabolites in aqueous samples and their GC-MS/MS analysis.

J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 967 , 134-8, (2014)

A simple two-step method for the derivatization of polar compounds (lactate, alanine, glycerol, succinate and glucose) using hexamethyldisilazane (HMDS) and N,O-bis(trimethylsilyl)trifluoroacetamide (...

Lactic acid production from acidogenic fermentation of fruit and vegetable wastes.

Bioresour. Technol. 191 , 53-8, (2015)

This work focused on the lactic acid production from acidogenic fermentation of fruit and vegetable wastes treatment. A long term completely stirred tank reactor (CSTR) lasting for 50 days was operate...

Related Compounds

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.