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PYRIDINE-2-CARBOXAMIDE

Names

[ CAS No. ]:
1452-77-3

[ Name ]:
PYRIDINE-2-CARBOXAMIDE

[Synonym ]:
pyridine-2-carboxamide
Picolinamide
2-Pyridinecarboxamide
2-Pyridinecarboximidic acid
2-PicolinaMide
EINECS 215-921-5
MFCD00023483

Biological Activity

[Description]:

Picolinamide (2-Picolinamide) is an inhibitor of Poly(ADP-ribose) synthetase of nuclei from rat pancreatic islet cells[1][3].

[Related Catalog]:

Signaling Pathways >> Epigenetics >> PARP
Research Areas >> Metabolic Disease
Signaling Pathways >> Cell Cycle/DNA Damage >> PARP

[Target]

Poly(ADP-ribose) synthetase[1]


[In Vitro]

Picolinamide (10 μM-1 mM) inhibits Poly(ADP-ribose) synthetase activity[2]. Picolinamide (2 mM) protects against streptozotocin-induced depression of proinsulin synthesis in isolated pancreatic islets of rats[3].

[In Vivo]

Picolinamide (4 mmol/kg, i.p., rats) inhibits Na+/phosphate cotransport by isolated renal brush border membrane vesicles[1]. Picolinamide (250 mg/kg, i.p., rats) enhances the tumorigenic effect of Streptozotocin and Alloxan on islet B-cells[4]. Animal Model: Rats[1] Dosage: 4 mmol/kg Administration: Intraperitoneal injection (i.p.) Result: Increased renal cortical NAD content (1.5 fold).

[References]

[1]. Campbell PI, et al. Specific inhibition of rat renal Na+/phosphate cotransport by picolinamide. J Pharmacol Exp Ther. 1989 Oct;251(1):188-92.

[2]. Uchigata Y, et al. Protection by superoxide dismutase, catalase, and poly(ADP-ribose) synthetase inhibitors against alloxan- and streptozotocin-induced islet DNA strand breaks and against the inhibition of proinsulin synthesis. J Biol Chem. 1982 Jun 10;257(11):6084-8.

[3]. Yamamoto H, et al. Protection by picolinamide, a novel inhibitor of poly (ADP-ribose) synthetase, against both streptozotocin-induced depression of proinsulin synthesis and reduction of NAD content in pancreatic islets. Biochem Biophys Res Commun. 1980 Jul 16;95(1):474-81.

[4]. amagami T, et al. Induction of rat pancreatic B-cell tumors by the combined administration of streptozotocin or alloxan and poly(adenosine diphosphate ribose) synthetase inhibitors. Cancer Res. 1985 Apr;45(4):1845-9.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
257.7±32.0 °C at 760 mmHg

[ Melting Point ]:
110 °C (dec.)(lit.)

[ Molecular Formula ]:
C6H6N2O

[ Molecular Weight ]:
122.125

[ Flash Point ]:
109.7±25.1 °C

[ Exact Mass ]:
122.048012

[ PSA ]:
55.98000

[ LogP ]:
-0.24

[ Vapour Pressure ]:
0.0±0.6 mmHg at 25°C

[ Index of Refraction ]:
1.590

MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi: Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S37/39

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
2933399090

Synthetic Route

Customs

[ HS Code ]: 2933399090

[ Summary ]:
2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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Related Compounds

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