5-Aminovaleric acid

Names

[ CAS No. ]:
660-88-8

[ Name ]:
5-Aminovaleric acid

[Synonym ]:
5-amino valeric acid
δ-Aminovaleric acid
EINECS 211-544-5
5-Aminopentanoic acid
Pentanoic acid, 5-amino-
5-Aminovaleric acid
MFCD00008232
H-5-Ava-OH

Biological Activity

[Description]:

5-Aminovaleric acid is believed to act as a methylene homologue of gamma-aminobutyric acid (GABA) and functions as a weak GABA agonist.

[Related Catalog]:

Research Areas >> Metabolic Disease

Research Areas >> Neurological Disease

Natural Products >> Others

[Target]

Human Endogenous Metabolite

[In Vitro]

5-Aminovaleric acid is a normal metabolite present in human saliva, with a tendency to elevated concentration in patients with chronic periodontitis[1]. 5-Aminovaleric acid is also believed to act as a methylene homologue of gamma-aminobutyric acid (GABA) and functions as a weak GABA agonist[2]. It is also known as an antifibrinolytic amino acid analog and so it functions as a weak inhibitor of the blood clotting pathway[3].

[References]

[1]. Syrjänen S, et al. Free amino-acid content of wax-stimulated human whole saliva as related to periodontal disease. Arch Oral Biol. 1987;32(9):607-10.

[2]. Callery PS, et al. 1-Piperideine as an in vivo precursor of the gamma-aminobutyric acid homologue 5-aminopentanoic acid. J Neurochem. 1985 Sep;45(3):946-8.

[3]. Cole KR, et al. The binding of antifibrinolytic amino acids to kringle-4-containing fragments of plasminogen. Arch Biochem Biophys. 1984 Mar;229(2):568-75.

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
247.5±23.0 °C at 760 mmHg

[ Melting Point ]:
158-161 °C(lit.)

[ Molecular Formula ]:
C₅H₁₁NO₂

[ Molecular Weight ]:
117.146

[ Flash Point ]:
103.5±22.6 °C

[ Exact Mass ]:
117.078979

[ PSA ]:
63.32000

[ LogP ]:
-0.34

[ Vapour Pressure ]:
0.0±1.0 mmHg at 25°C

[ Index of Refraction ]:
1.466

[ Storage condition ]:
Store at 0-5°C

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
Xn

[ Risk Phrases ]:
R20/21/22

[ Safety Phrases ]:
S22-S24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
2922499990

Synthetic Route

Click to get detail synthetic route

Customs

[ HS Code ]: 2922499990

[ Summary ]:
HS:2922499990 other amino-acids, other than those containing more than one kind of oxygen function, and their esters; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) MFN tariff:6.5% General tariff:30.0%

Articles

Peptide dimethylation: fragmentation control via distancing the dimethylamino group.

J. Am. Soc. Mass Spectrom. 25(10) , 1694-704, (2014)

Direct reductive methylation of peptides is a common method for quantitative proteomics. It is an active derivatization technique; with participation of the dimethylamino group, the derivatized peptid...

Detection of autosomal dominant polycystic kidney disease by NMR spectroscopic fingerprinting of urine.

Kidney Int. 79(11) , 1244-53, (2011)

Autosomal dominant polycystic kidney disease (ADPKD) is a frequent cause of kidney failure; however, urinary biomarkers for the disease are lacking. In a step towards identifying such markers, we used...

Highly sensitive GC/MS/MS method for quantitation of amino and nonamino organic acids.

Anal. Chem. 83(7) , 2705-11, (2011)

Metabolite profiling methods are important tools for measurement of metabolite pools in biological systems. While most metabolite profiling methods report relative intensities or depend on a few inter...

Related Compounds

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.