Isocitrate dehydrogenase

Names

[ Name ]:
Isocitrate dehydrogenase

[Synonym ]:
NADP-specific isocitric dehydyrogenase
NADPH-dependent isocitrate dehydrogenase
Oxalosuccinic decarboxylase
TPN-dependent isocitrate dehydrogenase
TPN-isocitrate dehydrogenase
TPN-linked isocitrate dehydrogenase
TPN-specific isocitrate dehydrogenase

Biological Activity

[Description]:

Isocitrate dehydrogenase (ICDH) is a citric acid or tricarboxylic acid cycle enzyme, is often used in biochemical studies. Isocitrate dehydrogenase catalyzes the oxidative decarboxylation of isocitrate to α-ketoglutarate and reduces NAD(P)+ to NAD(P)H, it plays important roles in cellular metabolism[1].

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> Isocitrate Dehydrogenase (IDH)

Research Areas >> Metabolic Disease

[References]

[1]. Reitman ZJ, Yan H. Isocitrate dehydrogenase 1 and 2 mutations in cancer: alterations at a crossroads of cellular metabolism. J Natl Cancer Inst. 2010 Jul 7;102(13):932-41.

Chemical & Physical Properties

[ Storage condition ]:
2-8°C

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;half-mask respirator (US);multi-purpose combination respirator cartridge (US)

[ RIDADR ]:
NONH for all modes of transport

Articles

[Effect of glyphosate on the energy exchange in carp organs].

Ukr. Biokhim. Zh. 85(3) , 22-30, (2013)

The use of glyphosate as a herbicide in agriculture can lead to the presence of its residues and metabolites (aminomethylphosphonic acid) in food for human consumption and pose a threat to health. The...

Genetic features of oligodendrogliomas and presence of seizures. The relationship of seizures and genetics in LGOs.

Clin. Neuropathol. 33(4) , 292-8, (2014)

Low grade oligodendrogliomas (LGO) are diffusely infiltrating World Health Organization (WHO) grade II gliomas, 20 - 30% of which show contrast enhancement. Seizures are a common presenting feature. I...

Controversies over the diagnosis of oligodendroglioma: a report from the satellite workshop at the 4th international symposium of brain tumor pathology, Nagoya Congress Center, May 23, 2012.

Brain Tumor Pathol. 30(4) , 253-61, (2013)

With the goal of discussing how the neuropathology community should resolve the controversy over the diagnosis of oligodendroglioma, this Satellite Workshop reflects the collaboration between two invi...

Related Compounds

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