56970-78-6

56970-78-6 structure

Name: Captopril EP Impurity D
Chemical Name: 3-bromo-2-methylpropionic acid
CAS Number: 56970-78-6
Molecular Formula: C₄H₇BrO₂
Molecular Weight: 167.00100
Catalog: analytical chemistry Standard Pharmacopoeia Standards and Magazine Standards
Create Date: 2018-02-23 08:00:00
Modify Date: 2024-01-02 17:32:22
Captopril EP Impurity D is an impurity of Captopril. Captopril (SQ-14534), antihypertensive agent, is a thiol-containing competitive, orally active angiotensin-converting enzyme (ACE) inhibitor (IC50=0.025 μM)[1][2][3].

Name	3-bromo-2-methylpropionic acid
Synonyms	methacrylic acid acid 3-BROMO-2-METHYL-PROPANOIC ACID 2-methyl 3-bromopropanoic acid 2-METHYL-3-BROMOPROPIONIC ACID 3-broMo-2-Methylbutanoate 3-BROMOISOBUTYRIC ACID Methyl-3-bromopropionicacid

Description	Captopril EP Impurity D is an impurity of Captopril. Captopril (SQ-14534), antihypertensive agent, is a thiol-containing competitive, orally active angiotensin-converting enzyme (ACE) inhibitor (IC50=0.025 μM)[1][2][3].
Related Catalog	Research Areas >> Others Signaling Pathways >> Others >> Others
References	[1]. ANCA GABRIELA CÂRJE, et al. HPLC-UV METHOD APPROACH FOR THE ANALYSIS AND IMPURITY PROFILING OF CAPTOPRIL. [2]. Afrin S, et al. Eritadenine from Edible Mushrooms Inhibits Activity of Angiotensin Converting Enzyme in Vitro. J Agric Food Chem. 2016;64(11):2263-2268. [3]. Esmaeili S, et al. Captopril/enalapril inhibit promiscuous esterase activity of carbonic anhydrase at micromolar concentrations: An in vitro study. Chem Biol Interact. 2017;265:24-35.

79-41-4

~92%

56970-78-6

Literature: Murakami; Hisaeda; Kohno; Ohno; Nishioka Bulletin of the Chemical Society of Japan, 1992 , vol. 65, # 11 p. 3094 - 3102

20609-71-6

~58%

56970-78-6

Literature: Salomon, Claudio J.; Mata, Ernesto G.; Mascaretti, Oreste A. Tetrahedron, 1993 , vol. 49, # 18 p. 3691 - 3734

HS Code	2915900090
Summary	2915900090 other saturated acyclic monocarboxylic acids and their anhydrides, halides, peroxides and peroxyacids; their halogenated, sulphonated, nitrated or nitrosated derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) MFN tariff:5.5% General tariff:30.0%