259728-61-5

259728-61-5 structure

Name: Funalenone
Chemical Name: 4,6,7,9-tetrahydroxy-8-methoxy-3-methylphenalen-1-one
CAS Number: 259728-61-5
Molecular Formula: C₁₅H₁₂O₆
Molecular Weight: 288.25
Catalog: Signaling Pathways Anti-infection Bacterial
Create Date: 2016-06-16 20:15:50
Modify Date: 2024-01-02 19:16:26
Funalenone (BMS-304245) is a MraY + MurG inhibitor with an IC50 of 25.5 μM in a MraY + MurG membrane plate assay. Funalenone inhibits Staphylococcus aureus (A15090) with an MIC of 64 μg/mL. Funalenone also inhibits MMP-1 with an IC50 of 170 μM[1][2].

Name	4,6,7,9-tetrahydroxy-8-methoxy-3-methylphenalen-1-one
Synonyms	8-deoxyxanthoherquein Funalenone 1H-Phenalen-1-one,3,4,7,9-tetrahydroxy-2-methoxy-6-methyl 3,4,7,9-tetrahydroxy-2-methoxy-6-methyl-1H-phenalen-1-one

Description	Funalenone (BMS-304245) is a MraY + MurG inhibitor with an IC50 of 25.5 μM in a MraY + MurG membrane plate assay. Funalenone inhibits Staphylococcus aureus (A15090) with an MIC of 64 μg/mL. Funalenone also inhibits MMP-1 with an IC50 of 170 μM[1][2].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Metabolic Enzyme/Protease >> MMP Signaling Pathways >> Metabolic Enzyme/Protease >> HIV Integrase Signaling Pathways >> Anti-infection >> Bacterial
Target	collagenases 1 HIV Integrase:10 μM (IC50)
References	[1]. J Inokoshi, et al. Funalenone, a novel collagenase inhibitor produced by Aspergillus niger. J Antibiot (Tokyo). 1999 Dec;52(12):1095-100. [2]. Zawadzke LE, et al. Targeting the MraY and MurG bacterial enzymes for antimicrobial therapeutic intervention. Anal Biochem. 2003 Mar 15;314(2):243-52. [3]. Kazuro Shiomi, et al. Fungal phenalenones inhibit HIV-1 integrase. J Antibiot (Tokyo). 2005 Jan;58(1):65-8. [4]. Inokoshi J, et al. Funalenone, a novel collagenase inhibitor produced by Aspergillus niger. J Antibiot (Tokyo). 1999 Dec;52(12):1095-100.