1070409-31-2

1070409-31-2 structure

Name: Palifosfamide tromethamine
Chemical Name: 2-amino-2-(hydroxymethyl)propane-1,3-diol,bis(2-chloroethylamino)phosphinic acid
CAS Number: 1070409-31-2
Molecular Formula: C₈H₂₂Cl₂N₃O₅P
Molecular Weight: 342.15700
Catalog: Signaling Pathways Cell Cycle/DNA Damage DNA Alkylator/Crosslinker
Create Date: 2017-10-09 20:12:26
Modify Date: 2024-01-30 11:22:19
Palifosfamide (tromethamine) is a synthetic alkylating agent with potential antineoplastic activity. As the stabilized active metabolite of ifosfamide, palifosfamide (tromethamine) irreversibly alkylates and crosslinks DNA through GC base pairs. This leads to an inhibition of DNA replication and ultimately cell death. Compared to ifosfamide, palifosfamide (tromethamine) is less toxic.

Name	2-amino-2-(hydroxymethyl)propane-1,3-diol,bis(2-chloroethylamino)phosphinic acid
Synonyms	ZIO-201-T UNII-0X5A3C04ID Palifosfamide tromethamine

Description	Palifosfamide (tromethamine) is a synthetic alkylating agent with potential antineoplastic activity. As the stabilized active metabolite of ifosfamide, palifosfamide (tromethamine) irreversibly alkylates and crosslinks DNA through GC base pairs. This leads to an inhibition of DNA replication and ultimately cell death. Compared to ifosfamide, palifosfamide (tromethamine) is less toxic.
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> DNA Alkylator/Crosslinker
References	[1]. Jones B, Komarnitsky P, Miller GT, Amedio J, Wallner BP. Anticancer activity of stabilized palifosfamide in vivo: schedule effects, oral bioavailability, and enhanced activity with docetaxel and doxorubicin. Anticancer Drugs. 2012;23(2):173-184.