1071992-81-8
1071992-81-8 structure
- Name: SM-433
- Chemical Name: (5S,8S,10aR)-5-[[(2S)-2-(methylamino)propanoyl]amino]-3-(3-methylbutanoyl)-6-oxo-N-[(2-phenylphenyl)methyl]-1,2,4,5,8,9,10,10a-octahydropyrrolo[1,2-a][1,5]diazocine-8-carboxamide
- CAS Number: 1071992-81-8
- Molecular Formula: C32H43N5O4
- Molecular Weight: 561.71
- Catalog: Signaling Pathways Apoptosis IAP
- Create Date: 2016-08-09 07:44:49
- Modify Date: 2024-04-05 19:12:26
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SM-433, a Smac mimetic, function as inhibitor of inhibitor of apoptosis proteins (IAPs). SM-433 exhibits strong binding affinity XIAP BIR3 protein with an IC50<1 μM. (patent WO2008128171A2)[1].
| Name | (5S,8S,10aR)-5-[[(2S)-2-(methylamino)propanoyl]amino]-3-(3-methylbutanoyl)-6-oxo-N-[(2-phenylphenyl)methyl]-1,2,4,5,8,9,10,10a-octahydropyrrolo[1,2-a][1,5]diazocine-8-carboxamide |
|---|---|
| Synonyms | unii-n65wc8pxdd |
| Description | SM-433, a Smac mimetic, function as inhibitor of inhibitor of apoptosis proteins (IAPs). SM-433 exhibits strong binding affinity XIAP BIR3 protein with an IC50<1 μM. (patent WO2008128171A2)[1]. |
|---|---|
| Related Catalog | |
| In Vitro | SM-433 exhibits strong inhibitory activity against MDA-MB -2131 human breast cancer cells and SK-OV-3 ovarian cancer cells (IC50s<10 μM, respectively)[1]. |
| References |
[1]. Shaomeng Wang, et al. Diazo bicyclic smac mimetics and the uses thereof. WO2008128171A2. |
| Molecular Formula | C32H43N5O4 |
|---|---|
| Molecular Weight | 561.71 |
| Exact Mass | 561.33200 |
| PSA | 117.83000 |
| LogP | 4.64780 |