1071992-81-8

1071992-81-8 structure

Name: SM-433
Chemical Name: (5S,8S,10aR)-5-[[(2S)-2-(methylamino)propanoyl]amino]-3-(3-methylbutanoyl)-6-oxo-N-[(2-phenylphenyl)methyl]-1,2,4,5,8,9,10,10a-octahydropyrrolo[1,2-a][1,5]diazocine-8-carboxamide
CAS Number: 1071992-81-8
Molecular Formula: C₃₂H₄₃N₅O₄
Molecular Weight: 561.71
Catalog: Signaling Pathways Apoptosis IAP
Create Date: 2016-08-09 07:44:49
Modify Date: 2024-04-05 19:12:26
SM-433, a Smac mimetic, function as inhibitor of inhibitor of apoptosis proteins (IAPs). SM-433 exhibits strong binding affinity XIAP BIR3 protein with an IC50<1 μM. (patent WO2008128171A2)[1].

Name	(5S,8S,10aR)-5-[[(2S)-2-(methylamino)propanoyl]amino]-3-(3-methylbutanoyl)-6-oxo-N-[(2-phenylphenyl)methyl]-1,2,4,5,8,9,10,10a-octahydropyrrolo[1,2-a][1,5]diazocine-8-carboxamide
Synonyms	unii-n65wc8pxdd

Description	SM-433, a Smac mimetic, function as inhibitor of inhibitor of apoptosis proteins (IAPs). SM-433 exhibits strong binding affinity XIAP BIR3 protein with an IC50<1 μM. (patent WO2008128171A2)[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Apoptosis >> IAP
In Vitro	SM-433 exhibits strong inhibitory activity against MDA-MB -2131 human breast cancer cells and SK-OV-3 ovarian cancer cells (IC50s<10 μM, respectively)[1].
References	[1]. Shaomeng Wang, et al. Diazo bicyclic smac mimetics and the uses thereof. WO2008128171A2.