SM-433

Modify Date: 2025-09-25 17:56:22

SM-433 Structure
SM-433 structure
 Common Name SM-433
CAS Number 1071992-81-8 Molecular Weight 561.71
Density N/A Boiling Point N/A
Molecular Formula C32H43N5O4 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of SM-433


SM-433, a Smac mimetic, function as inhibitor of inhibitor of apoptosis proteins (IAPs). SM-433 exhibits strong binding affinity XIAP BIR3 protein with an IC50<1 μM. (patent WO2008128171A2)[1].

 Names

Name (5S,8S,10aR)-5-[[(2S)-2-(methylamino)propanoyl]amino]-3-(3-methylbutanoyl)-6-oxo-N-[(2-phenylphenyl)methyl]-1,2,4,5,8,9,10,10a-octahydropyrrolo[1,2-a][1,5]diazocine-8-carboxamide
Synonym More Synonyms

 SM-433 Biological Activity

Description SM-433, a Smac mimetic, function as inhibitor of inhibitor of apoptosis proteins (IAPs). SM-433 exhibits strong binding affinity XIAP BIR3 protein with an IC50<1 μM. (patent WO2008128171A2)[1].
Related Catalog
In Vitro SM-433 exhibits strong inhibitory activity against MDA-MB -2131 human breast cancer cells and SK-OV-3 ovarian cancer cells (IC50s<10 μM, respectively)[1].
References

[1]. Shaomeng Wang, et al. Diazo bicyclic smac mimetics and the uses thereof. WO2008128171A2.

 Chemical & Physical Properties

Molecular Formula C32H43N5O4
Molecular Weight 561.71
Exact Mass 561.33200
PSA 117.83000
LogP 4.64780

 Synonyms

unii-n65wc8pxdd
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Chemsrc provides SM-433(CAS#:1071992-81-8) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of SM-433 are included as well.>> amp version: SM-433

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