SM-433
Modify Date: 2025-09-25 17:56:22
SM-433 structure
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Common Name | SM-433 | ||
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| CAS Number | 1071992-81-8 | Molecular Weight | 561.71 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C32H43N5O4 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of SM-433SM-433, a Smac mimetic, function as inhibitor of inhibitor of apoptosis proteins (IAPs). SM-433 exhibits strong binding affinity XIAP BIR3 protein with an IC50<1 μM. (patent WO2008128171A2)[1]. |
| Name | (5S,8S,10aR)-5-[[(2S)-2-(methylamino)propanoyl]amino]-3-(3-methylbutanoyl)-6-oxo-N-[(2-phenylphenyl)methyl]-1,2,4,5,8,9,10,10a-octahydropyrrolo[1,2-a][1,5]diazocine-8-carboxamide |
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| Synonym | More Synonyms |
| Description | SM-433, a Smac mimetic, function as inhibitor of inhibitor of apoptosis proteins (IAPs). SM-433 exhibits strong binding affinity XIAP BIR3 protein with an IC50<1 μM. (patent WO2008128171A2)[1]. |
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| Related Catalog | |
| In Vitro | SM-433 exhibits strong inhibitory activity against MDA-MB -2131 human breast cancer cells and SK-OV-3 ovarian cancer cells (IC50s<10 μM, respectively)[1]. |
| References |
[1]. Shaomeng Wang, et al. Diazo bicyclic smac mimetics and the uses thereof. WO2008128171A2. |
| Molecular Formula | C32H43N5O4 |
|---|---|
| Molecular Weight | 561.71 |
| Exact Mass | 561.33200 |
| PSA | 117.83000 |
| LogP | 4.64780 |
| unii-n65wc8pxdd |