DC Chemicals Limited
China
Product Name: KWD 2019
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Purity: 98.0%
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23031-25-6

23031-25-6 structure

Name: KWD 2019
Chemical Name: terbutaline
CAS Number: 23031-25-6
Molecular Formula: C₁₂H₁₉NO₃
Molecular Weight: 225.28400
Catalog: API Respiratory medication Asthma
Create Date: 2018-03-14 08:00:00
Modify Date: 2024-01-09 17:31:07
Terbutaline is a short-acting agonist of β2-adrenergic receptor (β2-AR) . Terbutaline is an active metabolite of bambuterol and used as a bronchodilator and to prevent premature labor[1][2].

Name	terbutaline
Synonyms	1-(3,5-dihydroxyphenyl)-2-(tert-butylamino)-ethanol TelMisartan API SNGP-003-04H08 MICARDIS [3H]-Telmisartan 4'-((1,4'-dimethyl-2'-propyl(2,6'-bi-1H-benzimidazol)-1'-yl)methyl)-(1,1'-biphenyl)-2-carboxylic acid BIBR 277 BIBR 277SE 4'-[(2-n-Propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)-benzimidazol-1-yl)-methyl]-2-carboxy-biphenyl 5-(1-Hydroxy-2-tert-butylamino-ethyl)benzene-1,3-diol TIMISHATAN Telmisaran 5-[2-(tertbutylamino)-1-hydroxyethyl]benzene-1,3-diol PRITOR 4'-[[2-n-propyl-4-methyl-6-(1-methylbenzimidazole-2-yl)-benzimidazol-1-yl]methyl]-biphenyl-2-carboxylic acid [3H]-Terbutaline EINECS 245-385-8 TU-199 TIMETAZIDINE

Description	Terbutaline is a short-acting agonist of β2-adrenergic receptor (β2-AR) . Terbutaline is an active metabolite of bambuterol and used as a bronchodilator and to prevent premature labor[1][2].
Related Catalog	Research Areas >> Endocrinology Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor
Target	Beta-2 adrenergic receptor
References	[1]. Hoffmann C, et al. Comparative pharmacology of human beta-adrenergic receptor subtypes--characterization of stably transfected receptors in CHO cells. Naunyn Schmiedebergs Arch Pharmacol. 2004 Feb;369(2):151-9. [2]. Gaudet LM, et al. Effectiveness of terbutaline pump for the prevention of preterm birth. A systematic review and meta-analysis. PLoS One. 2012;7(2):e31679.

Density	1.171 g/cm3
Boiling Point	419.2ºC at 760 mmHg
Melting Point	204-208ºC
Molecular Formula	C₁₂H₁₉NO₃
Molecular Weight	225.28400
Flash Point	165.3ºC
Exact Mass	225.13600
PSA	72.72000
LogP	1.91020
Vapour Pressure	3.42E-07mmHg at 25°C
Index of Refraction	1.4596 (estimate)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DN8960000

CHEMICAL NAME :: Benzyl alcohol, alpha-((t-butylamino)methyl)-3,5-dihydroxy-

CAS REGISTRY NUMBER :: 23031-25-6

LAST UPDATED :: 199612

DATA ITEMS CITED :: 8

MOLECULAR FORMULA :: C12-H19-N-O3

MOLECULAR WEIGHT :: 225.32

WISWESSER LINE NOTATION :: QR CQ EYQ1MX1&1&1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Multiple routes

SPECIES OBSERVED :: Human - woman

DOSE/DURATION :: 380 ug/kg

TOXIC EFFECTS :: Cardiac - other changes

REFERENCE :: JAMAAP JAMA, Journal of the American Medical Association. (AMA, 535 N. Dearborn St., Chicago, IL 60610) V.1- 1883- Volume(issue)/page/year: 244,692,1980

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - man

DOSE/DURATION :: 714 ug/kg

TOXIC EFFECTS :: Behavioral - tremor Cardiac - arrhythmias (including changes in conduction) Cardiac - change in rate

REFERENCE :: NEJMAG New England Journal of Medicine. (Massachusetts Medical Soc., 10 Shattuck St., Boston, MA 02115) V.198- 1928- Volume(issue)/page/year: 300,143,1979 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Multiple routes

DOSE :: 5660 ug/kg

SEX/DURATION :: female 32-34 week(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Newborn - Apgar score (human only) Reproductive - Effects on Newborn - biochemical and metabolic

REFERENCE :: JOPDAB Journal of Pediatrics. (C.V. Mosby Co., 11830 Westline Industrial Dr., St. Louis, MO 63141) V.1- 1932- Volume(issue)/page/year: 94,449,1979

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 6 mg/kg

SEX/DURATION :: female 17-19 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - respiratory system Reproductive - Specific Developmental Abnormalities - other developmental abnormalities

REFERENCE :: PEREBL Pediatric Research. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1967- Volume(issue)/page/year: 25,617,1989

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 30 mg/kg

SEX/DURATION :: female 17-19 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - Central Nervous System

REFERENCE :: BRBUDU Brain Research Bulletin. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1976- Volume(issue)/page/year: 23,263,1989

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 30 mg/kg

SEX/DURATION :: female 17-19 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - Central Nervous System Reproductive - Specific Developmental Abnormalities - endocrine system

REFERENCE :: RCOCB8 Research Communications in Chemical Pathology and Pharmacology. (PJD Pub. Ltd., P.O. Box 966, Westbury, NY 11590) V.1- 1970- Volume(issue)/page/year: 76,269,1992

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 62500 ng/kg

SEX/DURATION :: female 16-20 day(s) after conception

TOXIC EFFECTS :: Reproductive - Maternal Effects - other effects

REFERENCE :: BMMBES Biochemical Medicine and Metabolic Biology. (Academic Press, Inc., Journal Customer Service, POB 6250, Duluth, MN 55802-0250) V.35- 1986- Volume(issue)/page/year: 52,128,1994 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X4191 No. of Facilities: 58 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 1405 (estimated) No. of Female Employees: 941 (estimated)

RIDADR	UN 3077 9
HS Code	2942000000

HS Code	2922509090
Summary	2922509090. other amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

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