上海化源世纪贸易有限公司
上海市上海市普陀区
产品名：特布他林
纯度：98.0%
规格：
联系人：徐经理
联系电话：13311869306

上海源溪生物科技有限公司
上海市上海市浦东新区
产品名：KWD 2019
纯度：98.9%
规格：1g
联系人：赖经理
联系电话：13564518121

上海脉铂医药科技有限公司
上海市上海市嘉定区
产品名：Terbutaline
纯度：98.0%
规格：50mg/25mg/100mg/100mg
联系人：李先生
联系电话：18916172912

上海阿拉丁生化科技股份有限公司
上海市上海市浦东新区
产品名：特布他林
纯度：98.0%
规格：100mg/250mg/25mg/50mg
联系人：阿拉丁
联系电话：400-620-6333

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23031-25-6生产厂家

23031-25-6价格

23031-25-6

23031-25-6结构式

常用中文名：特布他林
常用英文名：KWD 2019
CAS号：23031-25-6
分子式：C₁₂H₁₉NO₃
分子量：225.28400
相关类别：原料药呼吸系统用药平喘药
发布时间：2018-03-14 08:00:00
更新时间：2024-01-09 17:31:07
特布他林是β2-肾上腺素能受体(β2-AR)的短效激动剂。特布他林是班布特罗的活性代谢物,用作支气管扩张剂和预防早产[1][2]。

化源商城直购

中文名	特布他林
英文名	terbutaline
中文别名	5-(1-羟基-2-叔丁基氨基乙基)苯-1,3-二酚
英文别名	1-(3,5-dihydroxyphenyl)-2-(tert-butylamino)-ethanol TelMisartan API SNGP-003-04H08 MICARDIS [3H]-Telmisartan 4'-((1,4'-dimethyl-2'-propyl(2,6'-bi-1H-benzimidazol)-1'-yl)methyl)-(1,1'-biphenyl)-2-carboxylic acid BIBR 277 BIBR 277SE 4'-[(2-n-Propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)-benzimidazol-1-yl)-methyl]-2-carboxy-biphenyl 5-(1-Hydroxy-2-tert-butylamino-ethyl)benzene-1,3-diol TIMISHATAN Telmisaran 5-[2-(tertbutylamino)-1-hydroxyethyl]benzene-1,3-diol PRITOR 4'-[[2-n-propyl-4-methyl-6-(1-methylbenzimidazole-2-yl)-benzimidazol-1-yl]methyl]-biphenyl-2-carboxylic acid [3H]-Terbutaline EINECS 245-385-8 TU-199 TIMETAZIDINE

描述	特布他林是β2-肾上腺素能受体(β2-AR)的短效激动剂。特布他林是班布特罗的活性代谢物,用作支气管扩张剂和预防早产[1][2]。
相关类别	研究领域 >> 内分泌信号通路 >> G 蛋白偶联受体/G 蛋白 >> 肾上腺素能受体
靶点	Beta-2 adrenergic receptor
参考文献	[1]. Hoffmann C, et al. Comparative pharmacology of human beta-adrenergic receptor subtypes--characterization of stably transfected receptors in CHO cells. Naunyn Schmiedebergs Arch Pharmacol. 2004 Feb;369(2):151-9. [2]. Gaudet LM, et al. Effectiveness of terbutaline pump for the prevention of preterm birth. A systematic review and meta-analysis. PLoS One. 2012;7(2):e31679.

密度	1.171 g/cm3
沸点	419.2ºC at 760 mmHg
熔点	204-208ºC
分子式	C₁₂H₁₉NO₃
分子量	225.28400
闪点	165.3ºC
精确质量	225.13600
PSA	72.72000
LogP	1.91020
蒸汽压	3.42E-07mmHg at 25°C
折射率	1.4596 (estimate)
分子结构	1、摩尔折射率：63.19 2、摩尔体积（cm³/mol）：192.2 3、等张比容（90.2K）：511.4 4、表面张力（dyne/cm）：50.0 5、极化率（10-24cm3）：25.05
计算化学	1.疏水参数计算参考值（XlogP）:无 2.氢键供体数量:4 3.氢键受体数量:4 4.可旋转化学键数量:4 5.互变异构体数量:5 6.拓扑分子极性表面积72.7 7.重原子数量:16 8.表面电荷:0 9.复杂度:205 10.同位素原子数量:0 11.确定原子立构中心数量:0 12.不确定原子立构中心数量:1 13.确定化学键立构中心数量:0 14.不确定化学键立构中心数量:0 15.共价键单元数量:1
更多	1.性状：结晶无水乙醚结晶 2.熔点（ºC）：119～122

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DN8960000

CHEMICAL NAME :: Benzyl alcohol, alpha-((t-butylamino)methyl)-3,5-dihydroxy-

CAS REGISTRY NUMBER :: 23031-25-6

LAST UPDATED :: 199612

DATA ITEMS CITED :: 8

MOLECULAR FORMULA :: C12-H19-N-O3

MOLECULAR WEIGHT :: 225.32

WISWESSER LINE NOTATION :: QR CQ EYQ1MX1&1&1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Multiple routes

SPECIES OBSERVED :: Human - woman

DOSE/DURATION :: 380 ug/kg

TOXIC EFFECTS :: Cardiac - other changes

REFERENCE :: JAMAAP JAMA, Journal of the American Medical Association. (AMA, 535 N. Dearborn St., Chicago, IL 60610) V.1- 1883- Volume(issue)/page/year: 244,692,1980

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - man

DOSE/DURATION :: 714 ug/kg

TOXIC EFFECTS :: Behavioral - tremor Cardiac - arrhythmias (including changes in conduction) Cardiac - change in rate

REFERENCE :: NEJMAG New England Journal of Medicine. (Massachusetts Medical Soc., 10 Shattuck St., Boston, MA 02115) V.198- 1928- Volume(issue)/page/year: 300,143,1979 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Multiple routes

DOSE :: 5660 ug/kg

SEX/DURATION :: female 32-34 week(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Newborn - Apgar score (human only) Reproductive - Effects on Newborn - biochemical and metabolic

REFERENCE :: JOPDAB Journal of Pediatrics. (C.V. Mosby Co., 11830 Westline Industrial Dr., St. Louis, MO 63141) V.1- 1932- Volume(issue)/page/year: 94,449,1979

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 6 mg/kg

SEX/DURATION :: female 17-19 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - respiratory system Reproductive - Specific Developmental Abnormalities - other developmental abnormalities

REFERENCE :: PEREBL Pediatric Research. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1967- Volume(issue)/page/year: 25,617,1989

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 30 mg/kg

SEX/DURATION :: female 17-19 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - Central Nervous System

REFERENCE :: BRBUDU Brain Research Bulletin. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1976- Volume(issue)/page/year: 23,263,1989

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 30 mg/kg

SEX/DURATION :: female 17-19 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - Central Nervous System Reproductive - Specific Developmental Abnormalities - endocrine system

REFERENCE :: RCOCB8 Research Communications in Chemical Pathology and Pharmacology. (PJD Pub. Ltd., P.O. Box 966, Westbury, NY 11590) V.1- 1970- Volume(issue)/page/year: 76,269,1992

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 62500 ng/kg

SEX/DURATION :: female 16-20 day(s) after conception

TOXIC EFFECTS :: Reproductive - Maternal Effects - other effects

REFERENCE :: BMMBES Biochemical Medicine and Metabolic Biology. (Academic Press, Inc., Journal Customer Service, POB 6250, Duluth, MN 55802-0250) V.35- 1986- Volume(issue)/page/year: 52,128,1994 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X4191 No. of Facilities: 58 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 1405 (estimated) No. of Female Employees: 941 (estimated)

危险品运输编码	UN 3077 9
海关编码	2942000000

3,5-二羟基苯甲酸和乙醇在硫酸催化下，回流反应，得到3,5-二羟基苯甲酸乙酯。在碳酸钾存在下3,5-二羟基苯甲酸乙酯和苄基氯，回流20h，用5mlo/L的盐酸或氢氧化钾水解为游离酸，和氯化亚砜一起回流1h，氯化为酰氯，和偶氮甲烷反应使成偶氮乙酰基，和溴化氢作用成为溴乙酰基，接着和叔丁胺回流20h。最后在乙酸存在下催化氢化得到特布他林。

海关编码	2922509090
中文概述	2922509090. 其他氨基醇酚、氨基酸酚及其他含氧基氨基化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件：AB. 最惠国关税:6.5%. 普通关税:30.0%
申报要素	品名, 成分含量, 用途, 乙醇胺及其盐应报明色度, 乙醇胺及其盐应报明包装
监管条件	A.入境货物通关单 B.出境货物通关单
检验检疫	R.进口食品卫生监督检验 S.出口食品卫生监督检验
Summary	2922509090. other amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

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