DC Chemicals Limited
China
Product Name: Brimonidine
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/500mg
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Brimonidine
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

59803-98-4

59803-98-4 structure

59803-98-4 structure

Name: Brimonidine
Chemical Name: brimonidine
CAS Number: 59803-98-4
Molecular Formula: C₁₁H₁₀BrN₅
Molecular Weight: 292.135
Catalog: API Special medicine Ophthalmic medication
Create Date: 2018-06-08 15:19:50
Modify Date: 2024-01-02 11:35:02
Brimonidine (UK 14304) is a full α2-adrenergic receptor (α2-AR) agonist.

Name	brimonidine
Synonyms	brimonidinum 5-bromo-6-(imidazolin-2-ylamino)-quinoxaline MFCD00153878 Brimonidine [INN:BAN] Bromoxidine Brimonidine 5-bromo-6-(2-imidazolin-2-ylamino)quinoxaline UNII-E6GNX3HHTE [3H]-Brimonidine 5-bromo-N-(4,5-dihydro-1H-imidazol-2-yl)quinoxalin-6-amine 5-Bromo-N-(4,5-dihydro-1H-imidazol-2-yl)-6-quinoxalinamine 6-Quinoxalinamine, 5-bromo-N-(4,5-dihydro-1H-imidazol-2-yl)- UK 14,304 brimonidina

Description	Brimonidine (UK 14304) is a full α2-adrenergic receptor (α2-AR) agonist.
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor Research Areas >> Others
Target	α2-adrenergic Receptor.
In Vitro	[3H]Brimonidine (UK 14304) is a full agonist at alpha 2-adrenergic receptors. [3H]Brimonidine (UK 14304) labels at least 2 specific binding sites in human brain that both have the characteristics of an alpha 2-adrenergic binding site. GTP decreases agonist binding at both of these sites, but with different potencies at each site [1-3].
References	[1]. Andorn, A.C., M.A. Carlson, and R.C. Gilkeson, Specific [3H]UK 14,304 binding in human cortex occurs at multiple high affinity states with alpha 2-adrenergic selectivity and differing affinities for GTP. Life Sci, 1988. 43(22): p. 1805-12. [2]. Cambridge, D., UK-14,304, a potent and selective alpha2-agonist for the characterisation of alpha-adrenoceptor subtypes. Eur J Pharmacol, 1981. 72(4): p. 413-5. [3]. Chopin, P., F.C. Colpaert, and M. Marien, Effects of alpha-2 adrenoceptor agonists and antagonists on circling behavior in rats with unilateral 6-hydroxydopamine lesions of the nigrostriatal pathway. J Pharmacol Exp Ther, 1999. 288(2): p. 798-804.

Density	1.8±0.1 g/cm3
Boiling Point	432.6±55.0 °C at 760 mmHg
Melting Point	207.5 °C
Molecular Formula	C₁₁H₁₀BrN₅
Molecular Weight	292.135
Flash Point	215.4±31.5 °C
Exact Mass	291.011963
PSA	62.20000
LogP	0.96
Vapour Pressure	0.0±1.0 mmHg at 25°C
Index of Refraction	1.798
Storage condition	Store at RT
Water Solubility	45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: <0.8 mg/mL

CHEMICAL IDENTIFICATION

RTECS NUMBER :: VD1200000

CHEMICAL NAME :: 6-Quinoxalinamine, 5-bromo-N-(4,5-dihydro-1H-imidazol-2-yl)-

CAS REGISTRY NUMBER :: 59803-98-4

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C11-H10-Br-N5

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 160 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JKXXAF Japanese Kokai Tokyo Koho Patents. (U.S. Patent and Trademark Office, Foreign Patents, Washington, DC 20231) Volume(issue)/page/year: #81-02912

Symbol	GHS06
Signal Word	Danger
Hazard Statements	H301
Precautionary Statements	P301 + P310
Hazard Codes	T:Toxic;
Risk Phrases	R25;R36/37/38
Safety Phrases	S26-S36-S45
RIDADR	UN 2811 6.1/PG 3
WGK Germany	-
RTECS	VD1200000
Packaging Group	III
Hazard Class	6.1
HS Code	2934999090

Precursor 0
DownStream 1
134892-42-5

HS Code	2934999090
Summary	2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%