CHEMICAL IDENTIFICATION
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RTECS NUMBER :
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BV8052000
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CHEMICAL NAME :
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5-alpha-Androstan-3-one, 17-beta-hydroxy-
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CAS REGISTRY NUMBER :
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521-18-6
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LAST UPDATED :
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199206
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DATA ITEMS CITED :
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19
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MOLECULAR FORMULA :
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C19-H30-O2
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MOLECULAR WEIGHT :
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290.49
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WISWESSER LINE NOTATION :
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L E5 B666 OVTJ A1 E1 FQ
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Subcutaneous
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DOSE :
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17500 ug/kg
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SEX/DURATION :
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female 35 day(s) pre-mating
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TOXIC EFFECTS :
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Reproductive - Fertility - female fertility index (e.g. # females pregnant per # sperm positive females; # females pregnant per # females mated)
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Subcutaneous
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DOSE :
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160 mg/kg
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SEX/DURATION :
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female 14-21 day(s) after conception
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TOXIC EFFECTS :
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Reproductive - Specific Developmental Abnormalities - urogenital system
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Subcutaneous
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DOSE :
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1400 ug/kg
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SEX/DURATION :
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female 14 day(s) pre-mating
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TOXIC EFFECTS :
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Reproductive - Maternal Effects - uterus, cervix, vagina Reproductive - Fertility - other measures of fertility
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Subcutaneous
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DOSE :
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700 ug/kg
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SEX/DURATION :
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female 14 day(s) pre-mating
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TOXIC EFFECTS :
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Reproductive - Maternal Effects - ovaries, fallopian tubes
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Intramuscular
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DOSE :
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80 mg/kg
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SEX/DURATION :
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female 13-20 day(s) after conception
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TOXIC EFFECTS :
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Reproductive - Specific Developmental Abnormalities - skin and skin appendages Reproductive - Specific Developmental Abnormalities - urogenital system
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Parenteral
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DOSE :
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2500 ug/kg
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SEX/DURATION :
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female 10 day(s) pre-mating
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TOXIC EFFECTS :
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Reproductive - Maternal Effects - ovaries, fallopian tubes
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Parenteral
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DOSE :
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168 mg/kg
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SEX/DURATION :
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male 1 day(s) pre-mating
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TOXIC EFFECTS :
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Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland, accessory glands
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Implant
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DOSE :
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24 mg/kg
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SEX/DURATION :
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male 42 day(s) pre-mating
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TOXIC EFFECTS :
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Reproductive - Paternal Effects - testes, epididymis, sperm duct Reproductive - Fertility - male fertility index (e.g. # males impregnating females per # males exposed to fertile nonpregnant females) Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured before birth)
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Unreported
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DOSE :
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150 mg/kg
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SEX/DURATION :
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female 30 day(s) pre-mating
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TOXIC EFFECTS :
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Reproductive - Maternal Effects - uterus, cervix, vagina
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Subcutaneous
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DOSE :
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40 mg/kg
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SEX/DURATION :
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female 1 day(s) pre-mating
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TOXIC EFFECTS :
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Reproductive - Maternal Effects - ovaries, fallopian tubes Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured before birth) Reproductive - Fertility - other measures of fertility
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Subcutaneous
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DOSE :
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40 mg/kg
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SEX/DURATION :
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female 10 day(s) pre-mating
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TOXIC EFFECTS :
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Reproductive - Maternal Effects - uterus, cervix, vagina Reproductive - Maternal Effects - other effects
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Subcutaneous
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DOSE :
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2 gm/kg
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SEX/DURATION :
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female 14 day(s) after conception
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TOXIC EFFECTS :
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Reproductive - Specific Developmental Abnormalities - skin and skin appendages
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Subcutaneous
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DOSE :
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24 mg/kg
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SEX/DURATION :
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female 3 day(s) after conception
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TOXIC EFFECTS :
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Reproductive - Maternal Effects - uterus, cervix, vagina
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Intramuscular
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DOSE :
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200 ug/kg
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SEX/DURATION :
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male 20 day(s) pre-mating
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TOXIC EFFECTS :
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Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count)
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Intramuscular
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DOSE :
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14 mg/kg
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SEX/DURATION :
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male 70 day(s) pre-mating
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TOXIC EFFECTS :
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Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count)
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Implant
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DOSE :
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3420 ug/kg
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SEX/DURATION :
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male 90 day(s) pre-mating
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TOXIC EFFECTS :
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Reproductive - Paternal Effects - testes, epididymis, sperm duct
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Subcutaneous
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DOSE :
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30 mg/kg
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SEX/DURATION :
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female 1-3 day(s) after conception
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TOXIC EFFECTS :
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Reproductive - Fertility - pre-implantation mortality (e.g. reduction in number of implants per female; total number of implants per corpora lutea)
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Unreported
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DOSE :
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1500 ug/kg
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SEX/DURATION :
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female 1-3 day(s) after conception
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TOXIC EFFECTS :
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Reproductive - Fertility - pre-implantation mortality (e.g. reduction in number of implants per female; total number of implants per corpora lutea)
MUTATION DATA
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TEST SYSTEM :
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Non-mammalian species
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DOSE/DURATION :
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12 mg/8W (Intermittent)
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REFERENCE :
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JEZOAO Journal of Experimental Zoology. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1904- Volume(issue)/page/year: 205,403,1978
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