91161-71-6
91161-71-6 structure
- Name: Terbinafine
- Chemical Name: terbinafine
- CAS Number: 91161-71-6
- Molecular Formula: C21H25N
- Molecular Weight: 291.430
- Catalog: API Synthetic anti-infective drugs Antifungal drugs
- Create Date: 2018-02-07 08:00:00
- Modify Date: 2026-07-01 12:33:52
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Terbinafine (TDT 067) is an antifungal medication used to treat fungal infections. It is a potent non-competitive inhibitor of squalene epoxidase from Candida with a Ki of 30 nM.
| Name | terbinafine |
|---|---|
| Synonyms |
1-Naphthalenemethanamine, N-(2E)-6,6-dimethyl-2-hten-4-ynyl-N-methyl
6-dimethyl-2-hten-4-ynyl)-n-methyl-n-((e)-1-naphthalenemethanamin Feline Terbinafine Intermediate [(2E)-6,6-diMethylht-2-en-4-yn-1-yl](Methyl)(naphthalen-1-ylMethyl)aMine Terbinafine alkaloid S1725_Selleck Feline Terbinafine Hydrochloride Intermediate (E)-6,6,N-Trimethyl-N-(1-naphtylmethyl)-2-htene-4-yne-1-amine Terbinafine (10mM in DMSO) MFCD00242672 N,6,6-Trimethyl-N-(naphthalen-1-ylmethyl)ht-2-en-4-yn-1-amine (6,6-Dimethyl-ht-2-en-4-ynyl)-methyl-naphthalen-1-ylmethyl-amine 1-Naphthalenemethanamine, N-[(2E)-6,6-dimethyl-2-hten-4-yn-1-yl]-N-methyl sf-86-327 Than naphthalene Finn Insulin Analogue Intermediate (2E)-N,6,6-Trimethyl-N-(naphthalen-1-ylmethyl)ht-2-en-4-yn-1-amine Lamisil AT TERBINAFINE (E)-N,6,6-trimethyl-N-(naphthalen-1-ylmethyl)hept-2-en-4-yn-1-amine (2E)-N,6,6-Trimethyl-N-(1-naphthylmethyl)hept-2-en-4-yn-1-amine Terbinafine-d3 (2E)-N,6,6-Trimethyl-N-(1-naphthylmethyl)-2-hepten-4-yn-1-amine rerbinafine EINECS 245-385-8 Lamasil (E)-N,6,6-Trimethyl-N-(naphthalen-1-ylmethyl)ht-2-en-4-yn-1-ylamine N-[(2E)-6,6-dimethyl-2-hten-4-yn-1-yl]-N-methyl-1-naphthalenemethanamine TerbinafineQ: What is Terbinafine Q: What is the CAS Number of Terbinafine Q: What is the storage condition of Terbinafine Q: What e the applications of Terbinafine (2E)-N,6,6-trimethyl-N-(1-naphthylmethyl)ht-2-en-4-yn-1-amine Terbinex trans-N-Methyl-N-(1-naphthylmethyl)-6,6-dimethylhept-2-en-4-ynyl-1-amine Lamisil (e)-n-(6,6-dimethyl-2-hten-4-ynyl)-n-methyl-1-naphthalenemethanamine (2E) N,6,6-Trimethyl-N-(napthalen-1-ylmethyl)ht-2-en-4-yn-1-amine (Terbinafine Base) 1-[[[(E)-6,6-Dimethyl-2-htene-4-ynyl](methyl)amino]methyl]naphthalene ( E)-N-Methyl-N-(1-naphthylMethyl)-6,6-diMethyl-ht-2-en-4-inyl-1-aMine Lamisil Tablet LAMISIL (E)-N-(6，6-I)imethyl-2-hten-4-ynyl)-N-methyl-1-naphthalenemethanamine UNII-G7RIW8S0XP (E)-N,6,6-trimethyl-N-(1-naphthylmethyl)ht-2-en-4-yn-1-amine N-[(E)-6,6-Dimethyl-2-hten-4-ynyl]-N-methyl-1-naphthalenemethanamine (E)-N,6,6-triMethyl-N-(naphthalen-1-ylMethyl)ht-2-en-4-yn-1-aMine trans-N-(6,6-Dimethyl-2-hten-4-ynyl)-N-methyl-1-naphthylmethylamine Terbinafine Impurity 1 TERBINAFINETERBINAFINE (E)-Terbinafine Lamasil (TN) Terbinafine //BP TDT 067 SF-86-327 N,6,6-Trimethyl-N-(naphthalen-1-ylmethyl)ht-2-en-4-yn-1-amine hydrochloride Terbinafine(LaMisil, Terbinex) |
| Description | Terbinafine (TDT 067) is an antifungal medication used to treat fungal infections. It is a potent non-competitive inhibitor of squalene epoxidase from Candida with a Ki of 30 nM. |
|---|---|
| Related Catalog | |
| Target |
Ki: 30 nM (squalene epoxidase)[1] |
| In Vitro | Terbinafine has a primary fungicidal action in vitro against most fungal pathogens, including dermatophytes, and dimorphic and filamentous fungi. Terbinafine specifically inhibits fungal ergosterol biosynthesis at the point of squalene epoxidation. The treated fungal cells rapidly accumulate tlic intermediate squalene and become deficient in the end-product of the pathway, ergosterol[1]. |
| In Vivo | Terbinafine is not only active after topical application but is very effective in experimental dermatophytoses following oral administration. In fungi infected guinea-pigs, the skin temperature dropps dramatically after the fourth treatment of terbinafine[2]. |
| Animal Admin | Guinea-pigs: The backs (lumbar regions) of guinea-pigs, which have been mechanically depilated, are infected with 0.1 mL Sabouraud's dextrose 2% broth containing 106 c.f.u. of Truhophyton mentagrophytes. The treatments commence 48 h post-inoculation. The test compounds (Terbinafine) are suspended in 2% tylose and Tween 80 and administered via a stomach tube once daily on 9 consecutive days, or dissolved in a mixture of polyethylene glycol 400 and etbanol and spread on the infected part ot the body in a volume of 0.4 mL with a Hrigalski spatula once daily for 1-7 consecutive days[2]. |
| References |
| Density | 1.0±0.1 g/cm3 |
|---|---|
| Boiling Point | 417.9±33.0 °C at 760 mmHg |
| Molecular Formula | C21H25N |
| Molecular Weight | 291.430 |
| Flash Point | 183.7±22.3 °C |
| Exact Mass | 291.198700 |
| PSA | 3.24000 |
| LogP | 6.61 |
| Vapour Pressure | 0.0±1.0 mmHg at 25°C |
| Index of Refraction | 1.586 |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
|
| Hazard Codes | Xi |
|---|---|
| Risk Phrases | 36/37/38 |
| Safety Phrases | S26-S36/37/39 |
| HS Code | 2921499090 |
| Precursor 8 | |
|---|---|
| DownStream 1 | |
| HS Code | 2921499090 |
|---|---|
| Summary | 2921499090 other aromatic monoamines and their derivatives; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0% |