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474-62-4

474-62-4 structure
474-62-4 structure
  • Name: Campesterol
  • Chemical Name: campesterol
  • CAS Number: 474-62-4
  • Molecular Formula: C28H48O
  • Molecular Weight: 400.680
  • Catalog: Research Areas Cancer
  • Create Date: 2018-04-17 08:00:00
  • Modify Date: 2025-08-21 19:33:57
  • Campesterol is a plant sterol with cholesterol lowering and anticarcinogenic effects.
Name campesterol
Synonyms Ergost-5-en-3β-ol, (24R)-
(24R)-Ergost-5-en-3b-ol
(24R)-5-Ergosten-3β-ol
EINECS 207-484-4
(3β,24R)-Ergost-5-en-3-ol
(24R)-5-Ergosten-3-β-ol
(3b,24R)-Ergost-5-en-3-ol
MFCD00010475
(24R)-Ergost-5-en-3β-ol
(24R)-5-Ergosten-3b-ol
Ergost-5-en-3-ol, (3β)-
Ergost-5-en-3β-ol
Campesterol
(24R)-Ergost-5-en-3-β-ol
(3β)-Ergost-5-en-3-ol
Ergost-5-en-3-β-ol
Ergost-5-en-3-ol, (3β,24R)-
Description Campesterol is a plant sterol with cholesterol lowering and anticarcinogenic effects.
Related Catalog
In Vitro Campesterol shows a weak cytotoxicity in non-proliferating human umbilical vein endothelial cells (HUVECs). Within the non-cytotoxic concentration range, campesterol significantly inhibits the bFGF-induced proliferation and tube formation of HUVECs in a concentration-dependent manner, while it does not affect the motility of HUVECs. 50 μg/mL of campesterol decreases the cell viability up to about 56% of control(IC50 of over 50 μg/mL)[1].
In Vivo Campesterol effectively disrupts the bFGF-induced neovascularization in chick chorioallantoic membrane (CAM) in vivo[1].
Cell Assay The effect of campesterol on the viable cell number was assessed by XTT assay. HUVECs were treated with various concentrations (10, 20, 30, 40 and 50 μg/mL) of campesterol and incubated at 37 °C in a humidified incubator for 24 h, a XTT working solution was added to each well. The cells were incubated at 37 °C for 2 h and the optical density was measured using a microplate reader at 450 nm[1].
References

[1]. Choi JM, et al. Identification of campesterol from Chrysanthemum coronarium L. and its antiangiogenic activities. Phytother Res. 2007 Oct;21(10):954-9.
Density 1.0±0.1 g/cm3
Boiling Point 489.5±14.0 °C at 760 mmHg
Melting Point 156-160ºC
Molecular Formula C28H48O
Molecular Weight 400.680
Flash Point 214.3±12.4 °C
Exact Mass 400.370514
PSA 20.23000
LogP 10.20
Vapour Pressure 0.0±2.8 mmHg at 25°C
Index of Refraction 1.522
Storage condition -20°C
Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H302-H312-H315-H319-H332-H335
Precautionary Statements P261-P280-P305 + P351 + P338
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes Xn: Harmful;T: Toxic;
Risk Phrases R20/21/22
Safety Phrases 26-36-45-36/37/39-23
RIDADR UN 1888 6.1/PG 3
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